Pharmacology of novel Chinese medicines screened for treatment of severe acute pancreatitis

Table 1 Effect of nine of Chinese herbal extracts on trypsin activity

Herbs	1	2	3	4	5	6	7	8	9
Activity change (± %)	-0.3	-6	-26	-12	-25	-17	-11	-5.1	-77

1: Chai Hu (Radix Bupleuri), 2: Bin Lang (Semen Arecae), 3: Da Huang, 4: Hu Lian (Rhizoma Picrorhizae), 5: Zhi Zi, 6:Huang Qin (Radix Scutellariae), 7: Hang Shao (Radix paeoniae Alba), 8: Mu Xiang (Radix Auxklandiae), 9: Yuan Hu

Table 2 Effect of nine of Chinese herbal extracts on elastase activity

Herbs	1	2	3	4	5	6	7	8	9
Activity change (± %)	-6	-6	13	5	-19	-26	-25	19	-90

Table 3 Effect of HHI-I on intestinal hymodynamics

	Before infusion	After infusion (min)
		20	40	60
BF (mL/min)	201.34 ± 70.21	225.00 ± 68.51a	245.40 ± 82.78b	252.20 ± 82.41b
OC (mL/min)	2.72 ± 1.09	4.92 ± 3.39	5.03 ± 2.55	5.33 ± 2.57a
(A-V)O2 (mL/100 mL)	1.47 ± 0.68	1.21 ± 1.34	2.16 ± 1.11a	2.29 ± 1.31
VR (kPa/mL/min)	0.10 ± 0.04	0.09 ± 0.04	0.08 ± 0.03a	0.08 ± 0.03a
HCT (%)	46.85 ± 10.58	47.73 ± 11.10	46.25 ± 10.47	45.20 ± 12.30

Five animals were tested. Data are expressed as (x^-± s_x-);

^aP < 0.05,

^bP≤ 0.01 vs. controls

Table 4 Effect of HHI-I on pancreatic oxygen tension and microcirculation

	Group	Before HHI-I	After HHI-I (min)
			20	40	60
Microcirculation	HHI-I	20.4 ± 5.0	49.0 ± 9.0a	51.0 ± 7.97b	54.8 ± 15.51b
(mL/min/100 g)	Control	32.4 ± 6.35	34.6 ± 3.65	34.2 ± 4.02	31.2 ± 5.71
Oxygen tension	HHI-I	6.21 ± 0.94	7.55 ± 1.40b	7.65 ± 1.76a	7.67 ± 1.64b
(kPa)	Control	5.60 ± 0.97	5.76 ± 1.07	5.49 ± 0.93	5.52 ± 0.79

Data are expressed as (x^-± s_x-);

^aP < 0.05;

^bP < 0.01 vs controls