Oncoprotein expression and inhibition of apoptosis during colorectal tumorigenesis

Table 1 Relationship between bcl-2 and p53 in clinico-pathological features of colorectal adenoma and carcinoma

Parameter	n	bcl-2		p53
		positive	%	positive	%
Adenoma size in mm
< 10	20	17	85.0	7	35.0
10-20	16	9	56.3	10	62.5
≥ 20	9	7	77.8	7	77.8a
Histological type
Tubular	20	14	70.0	10	50.0
Tubulovillous	7	5	71.4	4	57.1
Villous	18	14	77.8	10	55.6
Dysplasia
Mild	20	13	65.0	8	40.0
Moderate	18	15	83.3	10	55.6
Severe	4	4	100.0	3	75.0
Malignant change	3	1	33.3	3	100.0c
Serosal invasion
-	24	17	70.80	11	45.8
+	37	28	75.70	23	62.1
Well differentiated	13	10	76.90	4	30.8
Moderately differentiated	29	19	65.50	14	48.3
Poorly differentiated	12	11	91.67	10	83.3c
Mucinous	7	5	71.43	6	85.71
Lymph node metastasis
-	28	19	67.9	13	46.4
+	33	26	78.8	21	63.6
Duke's staging
A	17	12	70.6	5	29.4
B	9	5	55.6	7	77.8e
C	20	17	85.0	11	55.6
D	15	11	73.3	11	73.3a

^aP < 0.05, mild dysplasia vs malignant change; ^cP < 0.05, well differentiated vs poorly differentiated; ^eP < 0.05, Duke's stage B or D vs Duke's stage A.

Table 2 Correlation between bcl-2 and p53 staining¹ in adenomas and carcinomas

Pathology	n	Correlation coefficiency, r
Adenomas	45	-0.295
Carcinomas	61	-0.112

¹Positive label index.