Clinical outcome of pediatric collagenous gastritis: Case series and review of literature

Table 1 Demographic outline, treatment modalities, clinical course and outcome pooled cases of collagenous gastritis in children

Study	Age/gender	Treatment modalities	F/U	Histologic outcome	Clinical outcome
Colletti et al[2]	15/F	Ranitidine sucralfate and furazolidane	N/R	No pathological improvement	No clinical improvement
Côté et al[1]	9/F	Oral iron, sucralfate, omeprazole prednisolone	2.5	Unchanged subepithelial collagen bands Unchanged MN infiltrate Unchanged chronic active gastritis	Intermittent epigastric pain
Meunier et al[4]	11/M	Oral iron	6.25	Chronic atrophic gastritis Unchanged subepithelial collagen bands Increasing severity MN infiltrate	N/R
	12/F	Oral iron	0.6	Unchanged histologic findings	Asymptomtic
Winslow et al[13]	14/F	Sucralfate, ranitidine Misoprostol, furazolidone Clarithromycin Metronidazole Omeprazole, prednisone	12	Progressive chronic active gastritis Increasing severity MN infiltrate Development of intestinal metaplasia Linear endocrine cell hyperplasia Stable subepithelial collagen bands	Intermittent abdominal pain
Mahadevan et al[19]	15/F	Blood transfusion	0.5	Unchanged collagen band	N/R
Kori et al[6]	12/F	Oral iron Omeprazole Clarithromycin-based triple therapy	1	Severe erosive gastritis histologically and macroscopically	Intermittent nausea and vomiting Normalized weight gain
	12/F	Oral, intravenous iron Omeprazole Clarithromycin-based triple therapy, predinsone	6	Unchanged subepithelial collagen bands Stable MN infiltrate	Marked clinical improvement, normalized weight gain, anemia Resolved, intermittent epigastric pain
	12/F	Omeprazole	0.2	N/R	Improved abdominal pain and heartburn
Kamimura et al[15]	17/M	No therapy	14	Increased collagen band thickness, moderate MN cell infiltrate	Asymptomatic
Dray et al[14]	15/F	Oral iron, triple therapy Prolong PPI, predinsone	0.83	N/R	Clinical remission
Ravikumara et al[20]	9/F	Oral iron	4.1	Unchanged subepithelial collagen bands Stable MN infiltrate Decreased chronic gastritis	Asymptomatic
Leiby et al[17]	0.16/M	Steroids, PPI mesalamine Bismuth subsalicylate	6	N/R	CG clinical improvement relapse after finishing steroids
Brain et al[9]	16/F	Ranitidine Omeprazole Oral iron, exclusion diet	N/R	Unchanged histologic findings	Asymptomatic
Billiémaz et al[10]	0.75/M	Prednisolone Budesonide Parenteral nutrition Gluten free diet	14	Showed a diffuse atrophic mucosa and an increase in the subcutaneous collagen in the gastrointestinal tract	Complete clinical improvement with TPN
Suskind et al[11]	9/F	Oral iron	0.33	N/R	Asymptomatic
	15/M	Prednisone Lansoprazole Mesalamine	1	N/R	Asymptomatic
Leung et al[12]	15/F	Budesonide	3.4	Moderate gastric collagen deposition that decreased in thickness no IEL	Symptomatic improvement after therapy
	14/F	Pantoprazole Sucralfate	N/R	N/R	No improvement
	19/M	Sucralfate	0.25	Moderate gastric collagen deposition in body/fundus, no IEL	Symptomatic improvement
Wilson et al[16]	12/F	Oral iron	N/R	N/R	Aymptomatic Normalized weight gain
Camarero Salces et al[18]	9/F	Meslalazine	N/R	Unchanged	Unchanged
This series	11/M	Oral iron Omeprazole	5	Decreased/resolved collagen bands Decreased chronic gastritis Decreased MN infiltrate (fundic gland polyps)	Improved abdominal pain
	7/F	Oral iron Esomeprazole Budesonide/fish oil	1.5	Unchanged subepithelial collagen band	Improved abdominal pain

F/U: Duration of follow up (yr); IEL: Intraepithelial lymphocytosis; MN: Mononuclear; N/R: Not reported; TPN: Total parentral nutrition; F: Female; M: Male; CG: Collagenous gastritis; PPI: Proton-pump inhibitor.