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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 14, 2013; 19(6): 936-945
Published online Feb 14, 2013. doi: 10.3748/wjg.v19.i6.936
Published online Feb 14, 2013. doi: 10.3748/wjg.v19.i6.936
Study | Study type | Country | DM criteria | Age (yr) | Follow up (yr) | Least interval1 (yr) | Sex | DM prevalence | RR or OR (95%CI) | Adjustment variables/matched variable of selection | NOS | |
Atchison et al[53] | CS | United States (veterans) | Registration | 18-100 | 27 | 1 | Male | 13.2% | 0.95 (0.89-1.02) | Age, time, latency, race, number of visits, diagnoses of alcohol–related conditions, obesity and COPD | 8 | |
Carstensen et al[19] | CS | Denmark | Registration | No limit | 15 | Not mentioned | Male | 1.28 (1.15-1.43) | Age, calendar time, date of birth | 8 | ||
Female | 1.34 (1.14-1.58) | |||||||||||
Jiang et al[20] | CC | United States | Self reported | 30-74 | 1 | Both | 1.51 (1.10-2.07)2 | Age, sex, race, education, birth place, smoking and BMI | 7 (5)5 | |||
Lin et al[22] | CS | United States | Self reported | 50-71 | 10 | 2 | Male | 9.9% | 1.52 (1.21-1.92)2 | Age, calories, alcohol consumption, smoking, fruit consumption, vegetable consumption, ethnicity, education, and physical activity | 8 (6)5 | |
Female | 7.2% | 1.62 (0.98-2.68)2 | ||||||||||
Wotton et al[16] | ORLS1 | CS | England | Registration | ≥ 30 | 35 | 0 | Both | 5.5% | 1.11 (0.89-1.37) | Sex, age in 5-year bands, time and district of residence | 8 |
ORLS2 | 9 | 4.0% | 2.05 (1.30-3.10) | |||||||||
Chodick et al[54] | CS | Israel | Registration | ≥ 21 | 8 | 0 | Male | 1.44 (0.98-2.11) | Age, region, SES level, use of healthcare, BMI, and history of CVD/matched for age, sex | 8 | ||
Female | 0.99 (0.55-1.80) | |||||||||||
Ikeda et al[37] | CS | Japan | HbA1c (5.0%-5.9% vs 7.0%) | ≥ 40 | 14 | Not mentioned | Both | 3.9% | 2.69 (1.24-5.85) | Age, sex, H. pylori, history of peptic ulcer, BMI, TC, alcohol intake, smoking, dietary factor4 | 8 | |
Ogunleye et al[55] | CS | Scotland | Registration (only type 2 DM) | No limit | 11 | 1 | Both | 0.77 (0.36-1.66) | Deprivation deciles of Carstairs/matched for age, sex and doctor practice | 8 | ||
Kuriki et al[29] | CC | Japan | Self reported | 40-80 | Not mentioned | Male | 1.16 (0.93-1.44) | Age, BMI, drinking, smoking, exercise, bowel movement, FHx of cancer and DM, dietary restriction, vegetable intake, greasy food, snack | 6 | |||
Female | 1.70 (1.16-2.48) | |||||||||||
Inoue et al[27] | CS | Japan | Self reported | 40-69 | 13 | 5 | Male | 6.7% | 1.09 (0.79-1.5) | Age, study area, history of CVD and IHD, smoking, BMI, physical activity, alcohol, vegetable, coffee | 9 | |
Female | 3.0% | 1.92 (1.06-3.47) | ||||||||||
Jun et al[57] | NCC | Korea | FBS (< 99 mg/dL vs≥ 126 mg/dL) | ≥ 35 | Case 2.4/control 6.5 h | 2 | Both | 1.77 (0.57-5.45) | H. pylori, smoking, drinking, and education level/matched on age, sex, year and area of enrollment, and follow-up duration | 9 | ||
Khan et al[28] | CS | Japan | Self reported | 40-79 | 19 | 2 | Male | 7.5% | 0.72 (0.40-1.09) | Age, BMI, smoking, drinking | 8 | |
Female | 4.6% | 0.26 (0.08-0.82) | ||||||||||
Rapp et al[15] | CS | Austria | FBS (4.2-5.2 mmol/L vs 7.0 mmol/L) | > 19 | 14 | 1 | Male | 3.9% | 0.84 (0.38-1.87) | Age, smoking, occupation, BMI | 8 | |
Female | 3.0% | -3 | ||||||||||
Rousseau et al[56] | CC | Canada | Self reported | 35-70 | 2 | Male | 1.0 (0.5-1.8) | Age, income, education, ethnicity, proxy status, BMI, smoking, beta-carotene, alcohol | 7 | |||
Jee et al[26] | CS | South Korea | FBS (< 90 mg/dL vs≥ 126 mg/dL) or DM medication | 30-95 | 10 | 1 | Male | 5.1% | 1.11 (1.04-1.2) | Age, age squared, smoking, alcohol | 8 | |
Female | 4.5% | 1.15 (0.99-1.34) | ||||||||||
La Vecchia et al[25] | CC | Italy | Self reported | ≤ 75 | Not mentioned | Male | 0.6 (0.4-1.0) | Age | 6 | |||
Female | 0.7 (0.4-1.2) | |||||||||||
O'Mara et al[21] | CC | USA (only white) | Self reported | 30-89 | 1 | Male | 0.91 (0.28-2.27)2 | Age | 4 (3)5 | |||
Female | 1.57 (0.48-3.94) |
Studies (n) | RR (95%CI) | I2% (95%CI) | |
Overall | 27 | 1.19 (1.08-1.31) | 70.7 (56.8-80.2) |
Countries | |||
East Asian countries1 | 10 | 1.19 (1.02-1.38) | 60.1 (20.0-80.1) |
Western countries2 | 17 | 1.18 (1.03-1.36) | 75.6 (61.0-84.8) |
Study type | |||
Cohort study | 18 | 1.20 (1.08-1.34) | 75.5 (61.2-84.5) |
Case control study | 9 | 1.12 (0.87-1.45) | 57.9 (11.8-79.9) |
Sex | |||
Male | 12 | 1.10 (0.97-1.24) | 74.9 (55.7-85.8) |
Female | 9 | 1.24 (1.01-1.52) | 58.9 (14.1-80.3) |
DM criteria | |||
Registration | 8 | 1.21 (1.02-1.44) | 83.0 (67.8-91.0) |
Measured3 | 5 | 1.15 (1.01-1.32) | 35.5 (0.0-75.8) |
Self report | 14 | 1.13 (0.93-1.39) | 65.2 (38.6-80.3) |
Interval4 | |||
One and more years | 15 | 1.15 (1.02-1.31) | 67.5 (44.3-81.0) |
Quality (NOS) | |||
High quality (8 and more) | 17 | 1.17 (1.05-1.31) | 73.4 (57.0-83.6) |
Low quality (7 and less) | 10 | 1.20 (0.97-1.49) | 61.2 (22.6-80.5) |
Adjustment for risk factor | |||
Smoking5 | 12 | 1.17 (1.01-1.34) | 52.6 (8.7-75.4) |
H. pylori5 | 2 | 2.35 (1.24-4.46) | 0.0 (UC) |
Cancer site | |||
Cardia cancer | 2 | 1.39 (0.72-2.69) | 82.3 (UC) |
Noncardia cancer | 2 | 1.19 (0.80-1.77) | 59.6 (UC) |
- Citation: Yoon JM, Son KY, Eom CS, Durrance D, Park SM. Pre-existing diabetes mellitus increases the risk of gastric cancer: A meta-analysis. World J Gastroenterol 2013; 19(6): 936-945
- URL: https://www.wjgnet.com/1007-9327/full/v19/i6/936.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i6.936