Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 14, 2013; 19(6): 923-930
Published online Feb 14, 2013. doi: 10.3748/wjg.v19.i6.923
Table 1 Characteristics of 5616 cancer patients who received chemotherapy n (%)
CharacteristicsHematological malignancySolid tumorTotal
(n = 281)HCC(n = 237)Others(n = 5098)(n = 5616)
Age (yr), mean (range)50.5 (18-83)53.1 (39-67)54.4 (41-67)54.1 (29-79)
Sex
Men176 (62.6)201 (84.8)2567 (50.4)2944 (52.4)
Women105 (37.4)36 (17.9)2531 (49.6)2672 (47.6)
Surgical history22 (7.8)6 (2.5)2157 (42.3)2185 (38.9)
History of HBV infection127 (9.6)126 (53.2)179 (3.5)332 (5.9)
Aminotransferase
Normal (< 58 IU/mL)251 (89.3)144 (60.8)4816 (94.5)5211 (92.8)
Elevated30 (10.7)93 (39.2)282 (5.5)405 (7.2)
Table 2 Univariate logistic regression analysis of factors associated with testing for hepatitis B virus serological markers prior to chemotherapy, but excluding those tested preoperatively (n = 3431)
No.Screening n (%)P value
Age (yr)< 0.01
≤ 501215240 (19.8)
> 502216345 (15.6)
Sex< 0.05
Men2031374 (18.4)
Women1400211 (15.1)
Rituximab therapya< 0.01
Yes4925 (51.0)
No3382560 (16.6)
History of HBV infection< 0.01
Yes14145 (31.9)
No3290540 (16.4)
ALT and/or ASTb< 0.01
Abnormal205128 (62.4)
Normal3226457 (14.2)
Types of tumorc< 0.01
Hematological259112 (43.2)
Solid3172473 (14.9)< 0.05
Liver cancer7818 (23.1)
Others3094455 (14.7)
Table 3 Prevalence of hepatitis B virus serum markers and DNA in 2770 patients n (%)
No.HBsAg+HBsAb+HBeAg+HBeAb+Isolated HBcAb+HBV-sm positive1Screening HBV DNA2
Total2770372 (13.4)1367 (49.4)43 (1.6)600 (21.7)284 (10.3)656 (23.7)177 (27.0)
Age (yr)
≤ 20272 (7.4)14 (51.9)1 (3.7)2 (7.4)1 (3.7)3 (11.1)1 (33.3)
>202743370 (13.5)1353 (49.3)42 (1.5)598 (21.8)283 (10.3)653 (23.8)176 (27.0)
Sex
Women1495144 (9.6)780 (52.2)15 (1.0)280 (18.7)146 (9.8)290 (19.4)52 (17.9)
Men1275228 (17.9)587 (46.728 (2.2)320 (25.5)138 (10.8)366 (28.7)125 (34.2)
Types of tumor
Hematological13421 (15.7)51 (38.1)3 (2.2)26 (19.4)7 (5.2)28 (20.9)23 (82.1)
Solid2636351 (13.3)1316 (49.9)40 (1.5)574 (21.8)277 (10.5)628 (23.8)154 (24.5)
Liver cancer177114 (64.4)45 (25.4)17 (9.6)114 (64.4)27 (15.3)141 (79.7)68 (48.2)
Others2459207 (8.4)1271 (41.7)23 (0.9)114 (64.4)250 (10.2)487 (19.8)84 (3.5)
Table 4 Characteristics of 160 hepatitis B surface antigen-seropositive cancer patients undergoing cytotoxic chemotherapy n (%)
Patients developed HBV reactivation (n = 53)Patients who did not develop HBV reactivation (n = 107)P value
Sexa< 0.05
Men43 (38.4)69 (61.6)
Women10 (20.8)38 (79.2)
Age (yr), median (range)51.5 (24.8-78.2)52.9 (27.8-77.9)
Tumor typeb< 0.05
Lymphomas10 (55.6)8 (44.4)
Solid tumor43 (30.3)99 (69.7)
Liver cancer25 (35.7)45 (64.3)
Others18 (25.0)54 (75.0)
ALT levels, median (range) (normal < 58 IU/mL)69.1 (21.9-116.3)55.7 (18.2-93.2)
HBeAg statusc< 0.01
Positive17 (73.9)6 (26.1)
Negative36 (26.3)101 (73.7)
HBV DNA statusd< 0.01
Positive47 (45.2)57 (54.8)
Negative6 (10.7)50 (89.3)
Use of rituximab< 0.05
Yes6 (60)4 (40)
No47 (31.3)103 (68.7)
Use of corticosteroids< 0.05
Yes8 (61.5)5 (38.5)
No45 (30.6)102 (69.4)
Receiving antiviral therapy< 0.01
Yes1 (2.1)46 (97.9)
No52 (46.0)61 (54.0)