Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 14, 2013; 19(6): 889-896
Published online Feb 14, 2013. doi: 10.3748/wjg.v19.i6.889
Table 1 Baseline characteristics of the intent-to-treat patient population (n = 10)
Characteristic
Sex (female)9
Age, yr (mean ± SD)56.2 ± 9.7
Reason for NSAID therapy
Rheumatoid arthritis2
Osteoarthritis8
Medication use
Anti-hypertensive agents3
Anti-diabetic agents2
Low dose aspirinNA
Statin2
Table 2 Capsule endoscopy results according to Lewis Index Score evaluation of the small bowel mucosa at inclusion and 4 wk after mesalazine granules treatment
Subject No.First tertileSecond tertileThird tertileTotal LIS score
NSAID
1429304014043040
22254500450
316302252251630
4146220414621462
52472470247
611046545621104
713127121351312
836100361
9106810682251068
1016903931351690
NSAID + mesalazine
1900120812371208
2146216501462
32470247247
4106833910121068
511200112
610689002251068
7106810682331068
8225225135225
91104001104
101690155411041690
Table 3 Capsule endoscopy results of the patients with naproxen and naproxen + mesalazine granules therapy (n =10)
InclusionAfter mesalazine gran therapyP value
Total Lewis Index Score1236.4 ± 821.9925.2 ± 543.40.271
1st tertile952.8 ± 584.9894.4 ± 534.30.569
2nd tertile699.3 ± 877.9545.9 ± 580.90.649
3rd tertile415.3 ± 561.5319.3 ± 403.30.247
Ulcers with a diameter of > 3 mm, n
1st tertile871.000
2nd tertile860.625
3rd tertile341.000
Gastric transit time (min)43.8 ± 3249.8 ± 35.60.470
Small bowel transit time (min)261.9 ± 108250.9 ± 93.90.470
Cleanliness score1.3 ± 0.671.4 ± 0.690.345
Hemoglobin131.1 ± 5.8127.1 ± 7.80.103