Can mosapride citrate reduce the volume of lavage solution for colonoscopy preparation?

Table 1 Baseline characteristics

Variable	2.0 L	1.5 L	P value
Patients (n)	126	126
Age (yr, mean ± SD)	65.3 ± 9.9	66.3 ± 9.6	NS
< 60	30	25	NS
60 - < 70	51	44
≥ 70	45	53
Male	77	67	NS
Female	49	59
Indication (n)
Screening	40	41
Surveillance	67	63	NS
Diagnostic	19	22
Body mass index (kg/m2)	22.5 + 3.2	22.3 + 2.7	NS
Previous colonoscopy
None (first time)	44	41	NS
≥ 2	82	85
Previous preparation for colonoscopy (n)
2L PEG	82	85	NS

PEG: Polyethylene glycol; NS: Not significant.

Table 2 Overall colon-cleansing efficacy n (%)

Variable	Right side colon		Left side colon and rectum		P value1
	2.0 L	1.5 L	2.0 L	1.5 L	Right	Left
Patients (n)	122	122	122	122
Overall score (n)
Excellent	36	22	48	37	0.006	NS
Good	52	38	49	45
Fair	20	41	12	17
Poor	3	3	2	5
Inadequate	11	18	11	18
No. adequate	108 (88.5)	101 (82.8)	109 (89.3)	99 (81.1)	NS	NS

¹P value by χ² test. PEG: Polyethylene glycol; NS: Not significant.

Table 3 Results of preparation, endoscopic findings and patient questionnaire n (%)

Variable	2.0 L	1.5 L	P value
Patients	126	126
Time to first defecation (min, mean ± SD)	55.7 ± 27.4	56.4 ± 27.8	NS
Frequency of defecation (times, median, quartile)	7 (4-15)	7 (4-15)	NS
Time to preparation (min, mean ± SD)	157.3 ± 51.9	159.6 ± 57.1	NS
Elapsed time from last fluid intake to colonoscopy (min, mean ± SD)	169.4 ± 56.5	179.7 ± 61.1	NS
Cecal intubation rate	122 (96.8)	122 (96.8)	NS
Insertion time (min, median, quartile)1	11.4 (3-76)	10.1 (3-47)	NS
Feel of peristalsis	20 (16.4)	25 (20.5)	NS
Amount of irrigation fluid
None	38	41	NS
< 50 mL	74	74
50-100 mL	9	9
> 100 mL	5	2
Compliance > 80%	121 (96.0)	125 (99.2)	NS
100% intake	108 (85.7)	122 (96.8)	0.002
Any symptom
Nausea (none/mild/moderate/severe)	109/13/3/1	117/5/3/1	NS
Vomiting (none/mild/moderate/severe)	0/0/1/0	0/0/0/0	NS
Distension (none/mild/moderate/severe)	36/65/22/3	58/48/18/2	0.04
Abdominal pain (none/mild/moderate/severe)	98/26/2/0	107/18/1/0	NS
Circulatory reactions (none/mild/moderate/severe)	0	0	NS
Willingness to repeat
The same preparation regimen (much/fair/never)	78/19/29	97/12/17	0.034
How easy/difficult to take preparation compared to previous
(easy/no difference/difficult)	23/54/5	46/36/3	0.001

¹Insertion time was calculated without including the patients whose cecal portion was not examined. NS: Not significant.

Table 4 Characteristics of the endoscopic diagnosis n (%)

Variable	2.0 L		1.5 L		P value (2.0 L vs 1.5 L)
	Right side colon	Left side colon	Right side colon	Left side colon	Right	Left
Patients	126		126
Cancer patients	3	1	5	21	NS	NS
Polyp patients	74 (58.7)		73 (57.9)
Proportion of polyps
< 5 mm	60	62	65	70	NS	NS
5-10 mm	15	29	20	19
> 10 mm	6	5	8	5
Total polyps per study arm	81	96	93	94	NS	NS
Polyps per patient, mean ± SD	0.71 ± 1.19	0.79 ± 1.20	0.78 ± 1.19	0.78 ± 1.11	NS	NS
Diverticulosis	30		37

¹Advanced stenosing cancer. NS: Not significant.