Small bowel tumors detected and missed during capsule endoscopy: Single center experience

Table 1 Characteristics of the study population n (%)

Gender, males	71/145 (49)
Age
(min, max)	(8, 85)
mean (SD)	50.1 (19.2)
Main indication for CE1	n = 1502
Overt obscure bleeding	58 (38.7)
Occult obscure bleeding	23 (15.3)
Anemia	19 (12.7)
Malabsorption	18 (12.0)
Abnormal SB follow through	9 (6.0)
Abdominal pain	7 (4.7)
Celiac disease	5 (3.3)
Neuroendocrine tumor	3 (2.0)
Peutz-Jeghers syndrome	2 (1.3)
Diarrhea	2 (1.3)
Crohn’s disease	2 (1.3)
Polyposis syndrome	2 (1.3)

¹Primary indication was given;

²Capsule endoscopy (CE) was performed twice in 5 patients for the following reasons: incomplete examination (2 patients); recurring overt obscure gastrointestinal bleeding (OGIB) in a patient with normal first examination (1 patient) and recurring overt gastrointestinal bleeding in patients with abnormal first CE result and treatment instituted (mucosal breaks, angioectasias, 2 patients).

Table 2 Results of 150 capsule endoscopy examinations n (%)

Findings	n = 150
Significant findings
Angioectasias	25 (16.7)
Mucosal breaks	20 (13.3)
Tumor or polyp(s) ≥ 10 mm	15 (10.0)
Diverticula	14 (9.3)
Celiac disease	5 (3.3)
Active bleeding with no visible origin	3 (2.0)
Insignificant findings
Erythema or red spots	15 (10.0)
White spots	13 (8.7)
Other	7 (4.7)
Modeling of the bowel wall	2 (1.3)
Normal	29 (19.3)
Non-diagnostic	2 (1.3)

Table 3 Characteristics of patients with tumor or polyp(s) ≥ 10 mm detected on capsule endoscopy and the results of follow-up

No.	Age (yr)	Sex	Indication for CE	Bleeding on CE	CE reached the colon	DBE result	Surgery result	Neoplasm
1	21	F	PJS	-	√	NA	Dysplastic Peutz-Jeghers polyp	yes
2	25	M	Polyposis	-	-	NA	Dysplastic Peutz-Jeghers polyp	yes
3	30	M	Overt OGIB	-	-	NA	Meckel's diverticulum	no
4	36	F	Occult OGIB	√	-	NA	SB adenocarcinoma	yes
5	37	F	Occult OGIB	-	-	Dysplastic Peutz-Jeghers polyp in jejunum	Not operated on	yes
6	47	M	Malabsorption	√	√	NA	Unknown but benign	unknown
7	50	M	Abnormal SBFT	-	√	NA	Not operated on	unknown
8	53	M	Overt OGIB	√	-	NA	GIST	yes
9	53	M	PJS	-	√	NA	Dysplastic Peutz-Jeghers polyp	yes
10	56	M	Anemia, disseminated melanoma malignum	-	-	NA	Melanoma malignum metastasis	yes
11	59	F	Overt OGIB	√	√	Submucosal tumor	Venous malformation	no
12	60	F	Overt OGIB	-	√	NA	GIST	yes
13	64	F	Overt OGIB	-	√	NA	SB adenocarcinoma	yes
14	68	F	Occult OGIB	-	-	NA	Inflammatory tumor	no
15	68	F	Overt OGIB	-	√	NA	GIST	yes

CE: Capsule endoscopy; NA: Not applicable; DBE: Double-balloon enteroscopy; OGIB: Obscure gastrointestinal bleeding; SBFT: Small bowel follow through; PJS: Peutz-Jeghers syndrome; GIST: Gastro-intestinal stromal tumor; M: Male; F: Female.