Effectiveness of interferon-gamma release assays for differentiating intestinal tuberculosis from Crohn’s disease: A meta-analysis

Table 1 Summary of the included studies

Study	Country/Area	Patients (n)	Assay method	Cutoff	Test results				Quality score
					TP	FP	FN	TN	STARD	QUADAS
Lee et al[28]	South Korea	60	T-SPOT-TB	-	12	8	0	40	16	11
Lei et al[29]	China	191	T-SPOT-TB	-	36	5	6	62	18	13
Kim et al[30]	South Korea	128	QFT-G-IT	0.35 IU/mL	43	6	21	58	17	12
Li et al[31]	China	84	T-SPOT-TB	-	16	16	3	49	17	12
Kim et al[32]	South Korea	147	QFT-G-IT	0.35 IU/mL	50	7	25	65	18	13

T-SPOT-TB: An enzyme-linked immunosorbent spot assay; QFT-G-IT: Quanti-FERON-TB Gold In-Tube; TP: True-positive; FP: False-positive; FN: False-negative; TN: True-negative; STARD: Standards for reporting diagnostic accuracy; QUADAS: Quality assessment for studies of diagnostic accuracy.

Table 2 Characteristics of the included studies

Ref.	ITB/CD patients (n)	Reference standard	Cross-sectional design	Consecutive or random	Blinded design	Prospective
Lee et al[28]	12/44	Bac/His or Clin	Unknown	Yes	Unknown	Yes
Lei et al[29]	88/103	Bac/His	Unknown	Yes	No	Yes
Kim et al[30]	64/64	Bac/His	No	Yes	No	Yes
Li et al[31]	19/65	Bac/His or Clin	Yes	Yes	No	Yes
Kim et al[32]	75/72	Bac/His or Clin	No	Yes	No	Yes

ITB: Intestinal tuberculosis; CD: Crohn’s disease; Bac: Bacteriology; His: Histology; Clin: Clinical course.