Insulin-like growth factor-1 induces lymphangiogenesis and facilitates lymphatic metastasis in colorectal cancer

Table 1 Expression of insulin-like growth factor-1 and insulin-like growth factor-1 receptor in colorectal cancer tissues

	n	IGF-1	P value	IGF-1R	P value
Tissue type			0.001		0.002
Adjacent normal tissues	40	1.4 ± 0.6		1.3 ± 1.2
Cancer tissue	40	4.5 ± 2.5		4.7 ± 2.7
Differentiation			0.012		0.001
Well	9	3.0 ± 1.4		2.1 ± 0.9
Moderately	20	4.3 ± 2.6		4.6 ± 2.4
Poorly	11	6.1 ± 2.1		6.6 ± 2.1
Lymph node metastasis			0.003		0.002
Yes	15	6.8 ± 2.0		6.3 ± 2.2
No	25	3.1 ± 1.5		3.5 ± 2.2

IGF-I: Insulin-like growth factor-1; IGF-I R: Insulin-like growth factor-1 receptor.

Table 2 Lymphatic vessel density in colorectal cancer tissues

	n	LVD	P value
Tissue type			0.001
Adjacent normal tissues	40	3.3 ± 1.3
Cancer tissue	40	11.5 ± 3.0
Lymph node metastasis			0.032
Yes	15	12.7 ± 4.1
No	25	10.7 ± 3.9

LVD: Lymphatic vessel density.