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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2013; 19(43): 7701-7710
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7701
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7701
Table 1 Clinical characteristics of patients with Crohn’s disease
Characteristics | n = 506 |
Male/female | 251/255 |
Age at presentation (yr) | 31.5 ± 13.8 |
Median follow-up (yr) | 11.4 ± 7.8 |
Familial IBD | 12.9% |
Location (n) | |
L1 | 166 |
L2 | 182 |
L3 | 155 |
L4 only | 3 |
Behavior (n) | |
B1 | 288 |
At diagnosis B2 | 100 |
B3 | 118 |
Perianal disease | 25.5% |
Total steroid exposure/dependent-refractory | 68.6%/11.2% |
Total azathioprine exposure | 45.8% |
Total biological exposure | 9.1% |
Smoking habits (n) | |
No | 224 |
At diagnosis Ex | 38 |
Yes | 244 |
Table 2 Predictors of early limited surgery and drug exposures
Early surgery | No early surgery | P value | OR (95%CI) | |
Age at onset (A1) | 28.4% | 19.0% | 0.060 | 1.69 (0.97-2.96) |
Ileal location | 59.5% | 28.1% | < 0.001 | |
Colonic location | 13.5% | 39.9% | < 0.001 | |
Complicated behavior at diagnosis | 85.1% | 35.9% | < 0.001 | 10.2 (5.2-20.1) |
Overall steroid exposure | 52.7% | 71.3% | 0.001 | 0.45 (0.27-0.74) |
Steroid-dependent course | 2.6% | 12.3% | 0.070 | 0.19 (0.03-1.40 |
Overall biological exposure | 4.1% | 10.0% | 0.090 | 0.38 (0.12-1.26) |
Overall azathioprine exposure | 45.9% | 45.8% | > 0.050 |
Table 3 Factors associated with the need for early limited surgery in logistic regression analysis
P value | OR | 95%CI | |
Age at diagnosis | |||
A1 | 0.172 | 1.62 | 0.81-3.25 |
A2 | Reference | ||
Disease location | < 0.001 | ||
L1 | < 0.001 | 7.88 | 2.92-21.3 |
L3 | 0.035 | 3.21 | 1.09-9.48 |
L2 | Reference | ||
Disease behavior at diagnosis | < 0.001 | ||
B2 | < 0.001 | 4.91 | 2.15-11.2 |
B3 | < 0.001 | 7.66 | 3.52-16.7 |
B1 | Reference | ||
Smoking | |||
Yes | 0.487 | 1.24 | 0.68-2.27 |
No | Reference |
Table 4 Characteristics of patients with and without early resective surgery after matching on propensity scores
Table 5 Factors associated with the need for reoperation in Cox regression analysis
P value | HR | 95%CI | |
Early surgery1 | |||
Yes | 0.04 | 0.42 | 0.19-0.95 |
No | Reference | ||
Age at diagnosis | |||
A1 | 0.75 | - | - |
A2 | Reference | ||
Disease location | 0.95 | ||
L2 | 0.77 | - | - |
L3 | 0.95 | - | - |
L1 | Reference | ||
Disease behavior at diagnosis | 0.56 | ||
B2 | 0.30 | - | - |
B3 | 0.65 | - | - |
B1 | Reference | ||
Smoking | |||
Yes | 0.29 | - | - |
No | Reference |
- Citation: Golovics PA, Lakatos L, Nagy A, Pandur T, Szita I, Balogh M, Molnar C, Komaromi E, Lovasz BD, Mandel M, Veres G, Kiss LS, Vegh Z, Lakatos PL. Is early limited surgery associated with a more benign disease course in Crohn’s disease? World J Gastroenterol 2013; 19(43): 7701-7710
- URL: https://www.wjgnet.com/1007-9327/full/v19/i43/7701.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i43.7701