Pathophysiology of chronic pancreatitis

Table 1 Association with alcoholic chronic pancreatitis

Factor	Association
Drink type	Yes: Vonlaufen et al[83]
	Nakamura et al[84]
	No: Levy et al[29]
	Wilson et al[85]
Drinking pattern	Yes: Lankisch et al[18]
	No: Levy et al[29]
	Wilson et al[85]
Diet	Yes: Levy et al[29]
	No: Wilson et al[85]
Tobacco	Yes: Rebours et al[28]
	Maisonneuve[27]
	Imoto[26]
	Lowenfels[86]
	No: Levy[29]
	Haber et al[87]
Genetics	Yes: Whitcomb et al[24] (PRSS1-PRSS2 and X- linked CLDN 2)
	Rosendahl[88] (Chymotrypsin C gene mutation)
	Miyasaka et al[89] (Cholesteryl esterlipase polymorphism)
	Ockenga et al[90] (UDP-glucuronosyl transferase)
	Witt et al[91] (SPINK1 mutations)
	No: Schneider et al[92]
	Perri et al[93]
	Frenzer et al[94]
	Schneider et al[82]
	Norton et al[95]
	Haber et al[96]
	Wilson et al[85]

PRSS1: Cationic trypsinogen gene; PRSS2: Anionic trypsinogen gene; CLDN 2: Claudin 2 gene; UDP-glucuronosyltransferase: Uridine 5´-diphospho-glucuronosyltransferase; SPINK1: Serine protease inhibitor, kazal type 1, gene (encodes for pancreatic secretory trypsin inhibitor).