Estrogen improves the hyperdynamic circulation and hyporeactivity of mesenteric arteries by alleviating oxidative stress in partial portal vein ligated rats

Table 1 Hemodynamic data of the five animal groups and maximum contraction and EC50 in the five groups

	SO	PPVL + PLAC	PPVL + E2	PPVL + ICI	PPVL + E2 + ICI
Body weight (g)	248 ± 15	261 ± 22	245 ± 18	231 ± 23ac	244 ± 13
HR (bpm)	440 ± 32	412 ± 25a	415 ± 35a	419 ± 21a	406 ± 28a
MAP (mmHg)	95 ± 6	85 ± 11a	88 ± 9a	89 ± 5a	84 ± 8a
PP (mmHg)	4.6 ± 1.2	14.9 ± 0.9b	12.2 ± 1.6b	14.2 ± 1.5b	13.9 ± 1.3b
PV flow (mL/min)	8.52 ± 2.3	12.71 ± 3.1	9.76 ± 2.8	11.87 ± 3.5	13.04 ± 3.8
PVI (mL/min/100 g)	3.43 ± 1.2	4.87 ± 1.6a	3.98 ± 1.4c	5.14 ± 1.8a	5.34 ± 1.9a
CO (mL ∙ min-1)	54.68 ± 4.9	61.79 ± 5.9	52.07 ± 5.1	56.82 ± 5.6	57.91 ± 6.0
CI (Ml/min/100 g)	22.05 ± 1.9	23.67 ± 2.1	21.25 ± 2.0	24.60 ± 2.2	23.79 ± 2.5
SVR (mmHg∙min∙100 g/mL)	4.08 ± 0.48	3.38 ± 0.35b	3.95 ± 0.41c	3.50 ± 0.38a	3.32 ± 0.33a
SAR (mmHg∙min∙100 g/mL)	26.33 ± 2.7	14.39 ± 2.2b	19.29 ± 1.8bd	14.94 ± 1.7b	13.12 ± 1.5b
Emax	75.18% ± 4.52%	50.47% ± 3.48%a	70.65% ± 2.42%ad	51.37% ± 4.12%b	54.33% ± 4.71%b
EC50 (10-6 mol/L)	2.77 ± 0.74	5.27 ± 0.88b	3.77 ± 0.69bd	4.89 ± 0.76b	3.85 ± 0.52bd

Significant differences are marked with superscripts showing the P values.

^aP < 0.05,

^bP < 0.01 vs sham operation (SO);

^cP < 0.05,

^dP < 0.01 vs partial portal vein ligation (PPVL) + placobo (PLAC); E2: Estrogen; HR: Heart rate; MAP: Mean arterial pressure; PP: Portal pressure; PV: Portal vein; CO: Cardiac output; CI: Cardiac index; PVI: Portal venous inflow; SVR: Systemic vascular resistance; SAR: Splanchnic arteriolar resistance.