Impact of exome sequencing in inflammatory bowel disease

Table 1 Genes implicated as having coding variants in inflammatory bowel disease

Gene symbol	Description	Ref.
ADAM17	Disintegrin and metalloproteinase domain-containing protein 17	[57]
ATG16L1	Autophagy related 16-like 1	[7]
C1orf106	Chromosome 1 open reading frame 106	[46]
CARD9	Caspase recruitment domain family, member 9	[46]
CUL2	Cullin 2	[46]
DLG5	Discs-large 5	[58]
HEATR3	HEAT repeat containing 3	[59]
IL10RA and B	Interleukin-10 receptor	[34]
IL18RAP	Interleukin 18 receptor accessory protein	[46]
IL23R	Interleukin 23 receptor	[45]
LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	[60]
MDR1	Multi-drug resistance 1	[61]
MUC19	Mucin 19, oligomeric
NCF2	Neutrophil cytosolic factor 2	[62]
NDP52	Antigen nuclear dot 52 kDa Protein	[55]
NOD2	Nucleotide-binding oligomerization domain containing 2	[3,4]
PRDM1	PR domain containing 1, with Zinc finger domain	[55]
PTN22	Protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	[46]
SLC22A4	Solute carrier family 22 (organic cation/ergothioneine transporter), member 4	[63]
TNFRSF6B	Tumor necrosis factor receptor superfamily, member 6b, decoy	[47]