Age-dependent slowing of enteric axonal transport in insulin-resistant mice

Table 1 Number of mice at each age with tracer injection into the fundus or antrum

Age (wk)	Fundus	Antrum
KK mice
4	6	6
8	8	9
16	8	7
24	6	8
32	6	6
KKAy mice
4	6	6
8	6	6
16	6	6
24	6	7
32	5	6

Table 2 Animal characteristics

	Body weight (g)	HbA1c (%)	Urine glucose1
4 wk of age
KK	19.2 ± 0.4	< 4.0	0/6
	(n = 12)	(n = 3)
KKAy	19.9 ± 0.5	< 4.0	2/6
	(n = 12)	(n = 3)
8 wk of age
KK	29 ± 1d	5.0 ± 0.0	0/6
	(n = 17)	(n = 7)
KKAy	34 ± 1bd	6.6 ± 0.5b	1/31
	(n = 12)	(n = 6)
16 wk of age
KK	35 ± 1df	5.1 ± 0.1	0/13
	(n = 15)	(n = 3)
KKAy	43 ± 1bdf	7.5 ± 0.7b	8/111
	(n = 12)	(n = 3)
24 wk of age
KK	40 ± 1dfh	5.3	0/12
	(n = 14)	(n = 2)
KKAy	45 ± 1bdf	7.0 ± 0.9b	7/111
	(n = 13)	(n = 3)
32 wk of age
KK	39 ± 2df	5.0 ± 0.1	0/9
	(n = 12)	(n = 5)
KKAy	47 ± 1bdf	5.6 ± 0.5b	3/11
	(n = 11)	(n = 5)

¹Number of mice with urine glucose ≥ 500 mg/dL out of the total number of mice tested for urine glucose.

^bP < 0.01 vs KK;

^dP < 0.01 vs 4 wk;

^fP < 0.01 vs 8 wk;

^hP < 0.01 vs 16 wk. HbA1c: Haemoglobin A1c.