Influence of chronic HBV infection on superimposed acute hepatitis E

doi:10.3748/wjg.v19.i35.5904

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2013; 19(35): 5904-5909
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5904

Table 1 Demographic and clinical characteristics of the hepatitis B virus + hepatitis E virus group and hepatitis E virus group

	HBV + HEV group (n = 118)	HEV group (n = 176)	P values
Age (yr)	44.5 ± 13.8	54.1 ± 15.8	0.000¹
Sex			0.000¹
Male	109 (92.4)	140 (79.5)
Female	9 (7.6)	36 (20.5)
ALT (U/L)	266.0 ± 227.3	262.9 ± 212.9	0.905
AST (U/L)	228.9 ± 207.1	228.4 ± 213.1	0.986
PT (s)	22.1 ± 11.3	16.8 ± 7.9	0.000¹
PTA (%)	57.3 ± 26.6	77.2 ± 24.9	0.000¹
TBil (μmol/L)	334.7 ± 228.0	277.5 ± 217.4	0.031¹
MELD score	20.0 ± 9.7	15.1 ± 8.6	0.000¹
Complications	47 (39.8)	29 (16.5)	0.000¹
Liver failure	42 (35.6)	15 (8.5)	0.000¹
Death	24 (20.3)	13 (7.4)	0.002¹

¹Denotes significant P value. Data are expressed as absolute n (%) or mean ± SD. HBV: Hepatitis B virus; HEV: Hepatitis E virus; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PT: Prothrombin time; PTA: Prothrombin activity; TBil: Serum total bilirubin; MELD: Model for End-Stage Liver Disease.

Table 2 Influence of chronic hepatitis B virus infection on acute hepatitis E n (%)

	HBV + HEV group
	Status of HBeAg			Status of HBV DNA			Status of cirrhosis
	+ (n = 20)	- (n = 98)	P value	+ (n = 65)	- (n = 53)	P value	+ (n = 17)	- (n = 101)	P value
MELD score	17.0 ± 7.0	20.6 ± 10.1	0.131	21.5 ± 10.6	18.3 ± 8.3	0.074	24.7 ± 12.2	19.2 ± 9.1	0.03¹
Liver failure	5 (25)	37 (37.8)	0.317	25 (38.5)	17 (32.1)	0.563	11 (64.7)	31 (30.7)	0.01¹
Complications	7 (35)	40 (40.8)	0.803	25 (38.5)	22 (41.5)	0.850	16 (94.1)	31 (30.7)	0.00¹
Death	2 (10)	22 (22.4)	0.359	14 (21.5)	10 (19.9)	0.820	4 (23.5)	20 (19.8)	0.748

¹Denotes significant P value. HBV: Hepatitis B virus; HEV: Hepatitis E virus; HBeAg: Hepatitis B e antigen; MELD: Model for End-Stage Liver Disease.

Table 3 Anti-hepatitis B virus treatment in patients with liver failure in the hepatitis B virus + hepatitis E virus group

	Patients receiving anti-HBV treatment (n = 12)	Patients not receiving anti-HBV treatment (n = 30)	P value
HBV DNA (log₁₀ copies/mL)	4.99e7 ± 9.82e7	2.35e8 ± 9.20e8	0.495
MELD score	33.2 ± 9.4	28.3 ± 9.2	0.129
Mortality	8 (66.7)	53.3 (16/30)	0.506

Data are expressed as absolute n (%) or mean ± SD. HBV: Hepatitis B virus; HEV: Hepatitis E virus; MELD: Model for End-Stage Liver Disease.

Citation: Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H, Shu X, Ke WM, Li G, Xu QH. Influence of chronic HBV infection on superimposed acute hepatitis E. World J Gastroenterol 2013; 19(35): 5904-5909
URL: https://www.wjgnet.com/1007-9327/full/v19/i35/5904.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i35.5904