Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children

doi:10.3748/wjg.v19.i35.5897

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 21, 2013; 19(35): 5897-5903
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5897

Table 1 Demographic and biochemical features of patients with nonalcoholic fatty liver disease and normal controls

	NAFLD	Controls	P value
	(n = 250)	(n = 200)
Gender (M/F)	147/103	109/91	0.36
Age (yr)	10.78 ± 2.07	10.63 ± 2.22	0.47
Body height (cm)	148.28 ± 11.77	141.22 ± 12.91	0.00
Body weight (kg)	62.82 ± 15.17	34.72 ± 10.28	0.00
BMI (kg/m²)	28.13 ± 3.50	17.05 ± 2.16	0.00
SBP (mmHg)	114.02 ± 11.55	91.61 ± 9.68	0.00
DBP (mmHg)	68.57 ± 8.63	66.43 ± 7.67	0.01
Waist (cm)	89.84 ± 9.74	58.07 ± 7.04	0.00
Hip (cm)	93.85 ± 8.66	70.09 ± 7.85	0.00
WHR	0.95 ± 0.06	0.83 ± 0.05	0.00
FBG (mmol/L)	4.99 ± 0.41	4.91 ± 0.38	0.04
TCHO (mmol/L)	4.40 ± 0.89	4.14 ± 0.66	0.00
HDLc (mmol/L)	1.33 ± 0.51	1.52 ± 0.30	0.00
LDLc (mmol/L)	2.53 ± 0.72	2.19 ± 0.56	0.00
TG (mmol/L)	1.41 ± 0.84	0.80 ± 0.31	0.00
ALT (mmol/L)	72.70 ± 70.16	17.14 ± 10.48	0.00
AST (mmol/L)	47.26 ± 36.61	25.22 ± 6.53	0.00
FIN (mIU/L)	20.49 ± 17.25	6.98 ± 3.59	0.00
HOMA-IR	4.57 ± 3.92	1.52 ± 0.78	0.00

Data are expressed as absolute mean ± SD. Analysis was conducted using χ² test and t test. NAFLD: Nonalcoholic fatty liver disease; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic pressure; WHR: Waist-to-hip ratio; FBG: Fasting blood glucose; TCHO: Total cholesterol; HDLc: High-density lipoprotein-cholesterol; LDLc: Low-density lipoprotein-cholesterol; TG: Total triglyceride; ALT: Alanine transaminase; AST: Aspartate aminotransferase; FIN: Fasting insulin; HOMA-IR: Homeostasis model assessment-estimated insulin resistance; M: Male; F: Female.

Table 2 The genotypic distributions of the four loci in the UCP3 gene n (%)

		Genotypes			P value	Allele Frequency		P value
	n	Homozygous wild-type	Homozygous mutant-type	Heterozygous mutant-type	P value	Mutant-type	Wild-type	P value
rs1726745		GG	AA	AG		A	G
NAFLD	249	40 (16.1)	102 (41.0)	107 (43.0)	0.59	311 (62.4)	187 (37.6)	0.29
Controls	200	37 (18.5)	73 (36.5)	90 (45.0)	0.59	236 (59.0)	164 (41.0)	0.29
rs3781907		TT	CC	CT		C	T
NAFLD	239	87 (36.4)	42 (17.6)	110 (46.0)	0.23	194 (40.6)	284 (59.4)	0.19
Controls	198	57 (28.8)	37 (18.7)	104 (52.5)	0.23	178 (44.9)	218 (55.0)	0.19
rs11235972		GG	AA	AG		A	G
NAFLD	236	130 (55.1)	26 (11.0)	80 (33.9)	0.03	132 (28.0)	340 (72.0)	0.28
Controls	198	90 (45.5)	16 (8.0)	92 (46.5)	0.03	124 (31.3)	272 (68.7)	0.28
rs1800849		CC	TT	TC		T	C
NAFLD	249	133 (53.4)	25 (10.0)	91 (36.5)	0.14	141 (28.3)	357 (71.7)	0.54
Controls	199	92 (46.2)	16 (8.0)	91 (45.7)	0.14	123 (30.9)	275 (69.1)	0.54

NAFLD: Nonalcoholic fatty liver disease.

Table 3 Multivariate regression analysis for risk factors of nonalcoholic fatty liver disease (n = 449)

	B	SE	Wald	df	Sig	Exp (B)	95%CI for EXP (B)
	B	SE	Wald	df	Sig	Exp (B)	Lower	Upper
BMI	1.98	0.77	6.67	1	0.01	7.24	1.61	32.53
HOMA-IR	1.10	0.47	5.54	1	0.02	3.01	1.20	7.55
ALT	0.05	0.06	0.54	1	0.46	1.05	0.93	1.19
TCHO	-0.64	0.88	0.53	1	0.47	0.53	0.10	2.94
rs1800849	-7.28	40192.97	0	1	1	0	0	-
rs11235972	5.15	40192.97	0	1	1	172.72	0	-
rs3781907	1.09	2.01	0.30	1	0.59	2.98	0.06	151.89
rs1726745	-0.67	4.42	0.02	1	0.88	0.51	0	2933.6

TCHO: Total cholesterol; ALT: Alanine transaminase; HOMA-IR: Homeostasis model assessment-estimated insulin resistance; BMI: Body mass index.

Table 4 Demographic and biochemical features of subjects with and without rs1800849 variation (mean ± SD)

	Control			NAFLD
	CC (n = 92)	CT+TT (n = 107)	P value	CC (n = 133)	CT+TT (n = 116)	P value
Gender (M/F)	48/44	60/47	0.582	103/30	90/26	0.979
Body height (cm)	142.93 ± 13.08	139.38 ± 12.10	0.048	148.82 ± 12.50	147.83 ± 10.82	0.510
Body weight (kg)	35.65 ± 9.69	33.29 ± 8.51	0.070	64.42 ± 16.86	61.14 ± 12.74	0.083
BMI (kg/m²)	17.11 ± 2.00	16.86 ± 1.80	0.358	28.45 ± 3.75	27.79 ± 3.17	0.141
SBP (mmHg)	91.59 ± 8.89	91.29 ± 9.80	0.824	113.32 ± 11.74	114.84 ± 11.36	0.301
DBP (mmHg)	66.71 ± 7.11	66.13 ± 8.16	0.595	68.27 ± 9.13	68.91 ± 8.08	0.561
Waist (cm)	58.76 ± 6.45	57.00 ± 5.59	0.040	90.78 ± 10.58	88.87 ± 8.57	0.123
Hip (cm)	71.28 ± 7.84	69.06 ± 7.75	0.047	94.31 ± 9.51	93.47 ± 7.64	0.483
WHR	0.83 ± 0.05	0.83 ± 0.04	0.833	0.95 ± 0.07	0.95 ± 0.05	0.559
FBG (mmol/L)	4.91 ± 0.35	4.92 ± 0.40	0.888	5.02 ± 0.44	4.96 ± 0.36	0.245
TG (mmol/L)	4.11 ± 0.65	4.17 ± 0.67	0.519	4.32 ± 0.82	4.48 ± 0.96	0.165
HDL (mmol/L)	1.48 ± 0.29	1.55 ± 0.30	0.128	1.33 ± 0.58	1.35 ± 0.40	0.743
LDL (mmol/L)	2.18 ± 0.52	2.19 ± 0.58	0.950	2.50 ± 0.70	2.56 ± 0.75	0.457
ALT (mmol/L)	16.85 ± 6.44	16.48 ± 8.92	0.740	54.37 ± 2.07	51.43 ± 2.28	0.574
AST (mmol/L)	23.90 ± 5.54	26.07 ± 6.56	0.013	47.53 ± 36.24	46.91 ± 37.35	0.896
FINS	7.20 ± 3.34	6.62 ± 3.35	0.226	17.13 ± 2.11	14.86 ± 2.12	0.140
HOMA-IR	1.58 ± 0.75	1.45 ± 0.74	0.231	3.80 ± 2.14	3.27 ± 2.12	0.117

Analysis was conducted using t test. Statistically significant differences between groups are shown in bold. NAFLD: Nonalcoholic fatty liver disease; M: Male; F: Female; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic pressure; WHR: Waist-to-hip ratio; FBG: Fasting blood glucose; HDL: High-density lipoprotein-cholesterol; LDL: Low-density lipoprotein-cholesterol; TG: Total triglyceride; ALT: Alanine transaminase; AST: Aspartate aminotransferase; FIN: Fasting insulin; HOMA-IR: Homeostasis model assessment-estimated insulin resistance.

Table 5 Haplotype frequencies of rs1800849, rs11235972, rs3781907, rs1726745

Block	Frequencies		χ²	P value
Block	NAFLD	Control
GC	0.712	0.682	0.901	0.343
AT	0.282	0.307	0.702	0.402

NAFLD: Nonalcoholic fatty liver disease.

Citation: Xu YP, Liang L, Wang CL, Fu JF, Liu PN, Lv LQ, Zhu YM. Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children. World J Gastroenterol 2013; 19(35): 5897-5903
URL: https://www.wjgnet.com/1007-9327/full/v19/i35/5897.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i35.5897