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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 28, 2013; 19(32): 5278-5285
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5278
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5278
Characteristic | Patients (n = 46) |
Sex (M/F) | 30/16 |
Age (yr) | 57.9 ± 1.28 |
Time from OLT (mo) | 26.3 ± 5.1 |
ALT (IU/L) | 152.3 ± 17.8 |
AST (IU/L) | 105.9 ± 11.5 |
Gamma-GT (IU/L) | 188.7 ± 39.3 |
Alkaline phosphatases (IU/L) | 364.7 ± 39.9 |
Bilirubin (mg/L) | 1.7 ± 0.37 |
Viral load (log10) | 6.25 ± 0.09 |
Genotypes 1/4 vs 2/3 | 36/10 |
F1/F2/F3/F4 | 13/16/9/8 |
Fibrosing cholestatic hepatitis | 3 |
Cyclosporine A vs tacrolimus | 7/39 |
Variable | r | 95%CI | P-value |
BMI > 25 kg/m2 | 0.30 | 0.01455-0.5458 | 0.0400 |
Genotypes 2-3 vs 1-4 | 0.37 | 0.09103-0.5974 | 0.0100 |
RVR | 0.54 | 0.2992-0.7194 | 0.0001 |
HCV-RNA clearance during treatment | 0.82 | 0.6948-0.8967 | 0.0001 |
CyA vs FK immunosuppression | 0.41 | 0.09597-0.6519 | 0.0120 |
Grading | Staging | |||||
Before | After | P-value | Before | After | P-value | |
Sustained virological response (n = 9) | 7.2 ± 0.8 | 2.6 ± 0.6 | 0.0039 | 2.1 ± 0.3 | 1.0 ± 0.1 | 0.0031 |
Long-term treated (n = 19) | 7.9 ± 0.7 | 4.7 ± 0.6 | 0.0001 | 2.7 ± 0.3 | 2.5 ± 0.3 | 0.0001 |
Drop out (n = 7) | 7.4 ± 1.1 | 6.0 ± 0.8 | NS | 2.6 ± 0.6 | 3.0 ± 0.6 | NS |
- Citation: Tamè M, Buonfiglioli F, Del Gaudio M, Lisotti A, Cecinato P, Colecchia A, Azzaroli F, D’Errico A, Arena R, Calvanese C, Quarneti C, Ballardini G, Pinna AD, Mazzella G. Long-term leukocyte natural α-interferon and ribavirin treatment in hepatitis C virus recurrence after liver transplantation. World J Gastroenterol 2013; 19(32): 5278-5285
- URL: https://www.wjgnet.com/1007-9327/full/v19/i32/5278.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i32.5278