Colonic preparation before colonoscopy in constipated and non-constipated patients: A randomized study

Table 1 Bowel preparation quality grading score used by the endoscopists

Excellent	No fecal matter or nearly none in the colon, small-to-moderate amounts of clear liquids
Good	Small amounts of thin liquid fecal matter seen and easily suctioned, mainly distal to splenic flexure, small lesions may be missed, > 90% mucosa seen
Fair	Moderate amounts of thick liquid to semisolid fecal matter seen and suctioned, included proximal to splenic flexure, small lesions may be missed, 90% mucosa seen
Poor	Large amounts of solid fecal matter found, precluding a satisfactory study, unacceptable preparation; < 90% mucosa seen

Table 2 Characteristics of the included patients n (%)

Characteristics	Prep 1	Prep 2	Prep 3	Prep 4	P value
Patients	78	78	84	84
Age (yr), mean ± SD	59 ± 13.2	57 ± 11.1	60 ± 13.8	59 ± 10.9	NS
Sex
Male	37 (47)	40 (51)	41 (49)	45 (53)	NS
Female	41 (53)	38 (49)	43 (51)	39 (47)	NS
Constipation	21 (27)	16 (21)	15 (12)	24 (29)	NS
Successful cecal intubation	78 (100)	78 (100)	84 (100)	84 (100)	NS

NS: Not significant.

Table 3 Symptoms profile of different preparations n (%)

Adverse effects	Prep 1			Prep 2			Prep 3			Prep 4			P value
	Overall	Non-constipated (n = 59)	Constipated (n = 22)	Overall	Non-constipated (n = 58)	Constipated (n = 20)	Overall	Non-constipated (n = 69)	Constipated (n = 15)	Overall	Non-constipated (n = 65)	Constipated (n = 20)	Overall	Non-constipated	Constipated
Tolerability	62 (77)	47 (80)	15 (68)	63 (81)	47 (81)	16 (80)	69 (82)	57 (83)	12 (80)	71 (84)	53 (82)	18 (90)	NS	NS	NS
Nausea	27 (33)	17 (29)	10 (13)	30 (38)	24 (41)	6 (30)	26 (31)	2 (32)	4 (26)	25 (29)	18 (28)	7 (35)	NS	NS	NS
Vomiting	6 (7)	2 (3)	4 (18)	3 (4)	6 (10)	3 (15)	9 (11)	2 (3)	1 (7)	6 (7)	5 (8)	3 (15)	NS	NS	NS
Abdominal pain	13 (16)	8 (14)	5 (23)	21 (27)	18 (31)	3 (15)	16 (19)	14 (20)	2 (13)	24 (28)	19 (29)	5 (33)	0.2	< 0.051	NS
Bloating	25 (31)	17 (29)	8 (36)	21 (27)	15 (26)	6 (30)	27 (32)	22 (32)	5 (33)	24 (28)	16 (25)	8 (40)	NS	NS	NS
Insomnia	10 (12)	9 (15)	1 (5)	17 (21)	14 (24)	3 (15)	5 (6)	4 (6)	1 (7)	11 (13)	10 (15)	1 (5)	< 0.052	NS	NS
Dizziness	12 (15)	10 (17)	2 (9)	7 (9)	6 (10)	1 (5)	7 (8.3)	5 (7)	2 (13)	8 (9)	5 (8)	3 (15)	NS	NS	NS
Chest pain	1 (1)	1 (2)	0 (0)	2 (3)	1 (2)	1 (5)	1 (1)	1 (1)	0 (0)	1 (1)	0 (0)	1 (5)	NS	NS	NS

¹Prep 2 and 4 vs prep 1 and 3;

²prep 2 vs prep 1, 3 and 4. NS: Not significant.