Preoperative carcinoembryonic antibody is predictive of distant metastasis in pathologically T1 colorectal cancer after radical surgery

Table 1 Characteristics of 159 patients n (%)

Characteristics	With T1 colorectal cancer	Without metastasis(n = 153)	With metastasis(n = 6)	P value
Age, yr, mean ± SD	60.7 ± 11.7	60.48 ± 11.83	66.33 ± 7.012	0.231
Gender				0.099
Male	80 (50.3)	75	5
Female	79 (49.7)	78	1
Primary site				0.647
Cecum	3 (1.9)	3	0
Ascending colon	9 (5.7)	8	1
Transverse colon	6 (3.8)	6	0
Descending colon	6 (3.8)	5	1
Sigmoid colon	21 (13.2)	20	1
Rectosigmoid	8 (5.0)	8	0
Rectum	104 (65.4)	101	3
Anus canal	2 (1.3)	2	0
Pathology				0.919
Well differentiated	11 (6.9)	11	0
Moderately differentiated	83 (52.2)	79	4
Poorly differentiated	2 (1.3)	2	0
Mucinous	4 (2.5)	4	0
Localized canceration	59 (37.1)	57	2
Lymphnode metastasis				0.611
N0	146 (91.8)	141	5
N1	11 (6.9)	10	1
N2	2 (1.3)	2	0
CEA, ng/mL, mean ± SD	3.60 ± 4.01	3.29 ± 3.50	11.35 ± 7.87	0.054

CEA: Carcinoembryonic antibody.

Table 2 Risk factors for lymph node metastasis and distant metastasis in T1 colorectal cancer

Parameter	Odds ratio (95%CI)	P value
Lymph node metastasis
Age	1.015 (0.970, 1.062)	0.522
Gender	0.986 (0.329, 2.954)	0.980
Location	0.518 (0.138, 1.943)	0.330
Tumor size	0.859 (0.287, 2.574)	0.786
Histological grade	0.929 (0.748, 1.155)	0.509
CEA	0.445 (0.115, 1.805)	0.262
Distant metastasis
Age	1.050 (0.969, 1.138)	0.231
Gender	0.192 (0.022, 1.685)	0.137
Location	0.485 (0.095, 2.491)	0.386
Tumor size	0.563 (0.100, 3.163)	0.514
Histological grade	1.365 (0.957, 1.945)	0.086
LNM	2.154 (0.234, 19.850)	0.498
CEA (preoperation)	18.400 (3.106, 109.006)	0.001

CEA: Carcinoembryonic antibody; LNM: Lymph node metastasis.

Table 3 Details of distant metastasis patients

No.	Age (yr)	Gender	Location	CEA (ng/mL)	Histological grade	LNM	DFS	Recurrent site	Prognosis
1	62	Male	Ascending colon	13.66	Moderately differentiated	0/3	8	Liver and spleen	Diseased
2	61	Male	Descending colon	24.00	Localized canceration	0/15	23	Liver	Survived
3	68	Male	Rectum	15.00	Moderately differentiated	1/1	10	Liver	Survived
4	63	Female	Sigmoid colon	7.91	Moderately differentiated	0/10	30	Liver and lung	Diseased
5	80	Male	Rectum	5.20	Localized canceration	0/2	11	Liver	Survived

CEA: Carcinoembryonic antibody; LNM: Lymph node metastasis; DFS: Disease-free survival.