Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 7, 2013; 19(25): 4023-4030
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4023
Table 1 Selected characteristics of the study subjects
CharacteristicsCasesControls
(n = 455)(n = 1052)
Age (yr), mean ± SD52.4 ± 0.852.4 ± 0.9
Body mass index (kg/m2), mean ± SD24.1 ± 2.823.7 ± 2.5
MET-h/wk, median (IQR)112 (3-24)14 (5-24)
Smoking (cigarette-yr)
020.90%33.70%
1-39914.10%18.80%
400-79945.50%33.70%
≥ 80019.60%13.70%
Alcohol use (mL/d)
Never11.20%13.80%
Past2.90%3.10%
< 3021.10%30.70%
30-5934.10%28.70%
≥ 6030.80%23.70%
Table 2 Associations between genetic polymorphisms and colorectal adenomas n (%)
GenotypeCasesControlsCrudeAdjusted3
OR (95%CI)
CYP1A1*2A
01174 (38.2)388 (36.9)1.00 (referent)1.00 (referent)
1219 (48.1)508 (48.3)0.96 (0.76-1.22)0.97 (0.76-1.24)
262 (13.6)156 (14.8)0.89 (0.63-1.25)0.86 (0.60-1.23)
CYP1A1*2C
01281 (61.8)611 (58.1)1.00 (referent)1.00 (referent)
1152 (33.4)389 (37.0)0.85 (0.67-1.07)0.81 (0.64-1.03)
222 (4.8)52 (4.9)0.92 (0.55-1.54)0.94 (0.55-1.60)
GSTM1
Non-null200 (44.0)506 (48.1)1.00 (referent)1.00 (referent)
Null255 (56.0)546 (51.9)1.18 (0.95-1.47)1.19 (0.94-1.49)
GSTT1
Non-null258 (56.7)552 (52.5)1.00 (referent)1.00 (referent)
Null197 (43.3)500 (47.5)0.84 (0.68-1.05)0.87 (0.70-1.10)
GSTM1 + GSTT1
02118 (25.9)273 (26.0)1.00 (referent)1.00 (referent)
1222 (48.8)512 (48.7)1.00 (0.77-1.31)1.04 (0.79-1.37)
2 (both null)115 (25.3)267 (25.4)1.00 (0.73-1.35)1.04 (0.76-1.42)
NQO1 C609T
CC161 (35.4)412 (39.2)1.00 (referent)1.00 (referent)
CT220 (48.4)489 (46.5)1.15 (0.90-1.47)1.18 (0.92-1.52)
TT74 (16.3)151 (14.4)1.25 (0.90-1.75)1.31 (0.93-1.84)
Table 3 Associations between combinations of genetic polymorphisms and colorectal adenomas
Genotype 1Genotype 2n1OR (95%CI)2Interaction (P)
CYP1A1*2AGSTM10.94
03Non-null75/1821.00 (referent)
0Null99/2061.20 (0.83-1.74)
≥ 1Non-null125/3240.96 (0.67-1.35)
≥ 1Null156/3401.12 (0.80-1.58)
CYP1A1*2AGSTT10.08
03Non-null92/2101.00 (referent)
0Null82/1781.14 (0.79-1.65)
≥ 1Non-null166/3421.15 (0.83-1.58)
≥ 1Null115/3220.85 (0.61-1.19)
CYP1A1*2AGSTM1 + GSTT10.44
030441/1021.00 (referent)
0185/1881.19 (0.75-1.88)
02 (both null)48/981.35 (0.81-2.27)
≥ 1077/1711.17 (0.74-1.86)
≥ 11137/3241.12 (0.73-1.72)
≥ 12 (both null)67/1691.03 (0.64-1.66)
CYP1A1*2ANQO1 C609T0.09
03CC63/1331.00 (referent)
0CT + TT111/2550.92 (0.63-1.36)
≥ 1CC98/2790.73 (0.49-1.07)
≥ 1CT + TT183/3851.02 (0.71-1.47)
CYP1A1*2CGSTM10.77
03Non-null127/2941.00 (referent)
0Null154/3171.16 (0.86-1.55)
≥ 1Non-null73/2120.79 (0.56-1.12)
≥ 1Null101/2290.98 (0.71-1.36)
CYP1A1*2CGSTT10.24
03Non-null154/3211.00 (referent)
0Null127/2900.97 (0.73-1.31)
≥ 1Non-null104/2310.93 (0.68-1.27)
≥ 1Null70/2100.69 (0.49-0.97)
CYP1A1*2CGSTM1 + GSTT10.37
03474/1561.00 (referent)
01133/3030.96 (0.67-1.37)
02 (both null)74/1521.13 (0.75-1.69)
≥ 1044/1170.79 (0.50-1.25)
≥ 1189/2090.92 (0.63-1.35)
≥ 12 (both null)41/1150.72 (0.45-1.15)
CYP1A1*2CNQO1 C609T0.05
03CC102/2201.00 (referent)
0CT + TT179/3910.99 (0.73-1.34)
≥ 1CC59/1920.61 (0.42-0.91)
≥ 1CT + TT115/2490.98 (0.71-1.37)
Table 4 Associations between genetic polymorphisms and colorectal adenomas with stratification by smoking category
Genotype< 20 pack-years
20 pack-years
Interaction (P)
n1OR (95%CI)2n1OR (95%CI)2
CYP1A1*2A
0359/2071.00 (referent)115/1812.22 (1.52-3.24)0.45
≥ 1100/3461.05 (0.73-1.53)181/3181.95 (1.37-2.76)
CYP1A1*2C
03106/3291.00 (referent)175/2821.90 (1.41-2.56)0.59
≥ 153/2240.76 (0.52-1.11)121/2171.65 (1.20-2.27)
GSTM1
Non-null69/2641.00 (referent)131/2421.99 (1.41-2.82)0.96
Null90/2891.19 (0.83-1.71)165/2572.35 (1.68-3.29)
GSTT1
Non-null89/2681.00 (referent)169/2841.74 (1.27-2.38)0.26
Null70/2850.74 (0.52-1.06)127/2151.69 (1.21-2.36)
GSTM1 + GSTT1
0439/1341.00 (referent)79/1391.87 (1.18-2.96)0.63
180/2641.03 (0.67-1.61)142/2481.91 (1.26-2.91)
2 (both null)40/1550.89 (0.54-1.48)75/1122.14 (1.34-3.43)
NQO1 C609T
CC52/2211.00 (referent)109/1912.23 (1.51-3.29)0.46
CT + TT107/3321.35 (0.93-1.97)187/3082.51 (1.75-3.60)
Table 5 Associations between combinations of genetic polymorphisms and colorectal adenomas with stratification by smoking category
Genotype 1Genotype 2< 20 pack-years
20 pack-years
Interaction (P)
n1OR (95%CI)2n1OR (95%CI)2
CYP1A1*2AGSTM10.44
03Non-null25/871.00 (referent)50/951.78 (1.00-3.14)
0Null34/120  0.94 (0.52-1.69)65/862.53 (1.45-4.43)
≥ 1Non-null44/177  0.86 (0.49-1.50)81/1471.82 (1.07-3.10)
≥ 1Null56/169  1.19 (0.69-2.05)100/1711.92 (1.14-3.22)
CYP1A1*2AGSTT10.56
03Non-null29/981.00 (referent)63/1121.94 (1.15-3.28)
0Null30/109  0.95 (0.53-1.71)52/692.53 (1.44-4.44)
≥ 1Non-null60/170  1.26 (0.75-2.11)106/1722.07 (1.27-3.39)
≥ 1Null40/176  0.81 (0.47-1.40)75/1461.70 (1.02-2.82)
CYP1A1*2AGSTM1 + GSTT10.40
030414/421.00 (referent)27/601.34 (0.62-2.89)
0126/101  0.76 (0.36-1.62)59/872.02 (1.00-4.07)
02 (both null)19/64  0.87 (0.39-1.94)29/342.46 (1.11-5.46)
≥ 1025/92  0.83 (0.39-1.78)52/791.89 (0.93-3.86)
≥ 1154/163  1.01 (0.51-2.01)83/1611.52 (0.78-2.98)
≥ 12 (both null)21/91  0.73 (0.33-1.59)46/781.66 (0.81-3.40)
CYP1A1*2ANQO1 C609T0.76
03CC20/731.00 (referent)43/602.55 (1.34-4.86)
0CT + TT39/134  1.04 (0.56-1.94)72/1212.15 (1.20-3.86)
≥ 1CC32/148  0.81 (0.43-1.54)66/1311.69 (0.94-3.04)
≥ 1CT + TT68/198  1.29 (0.72-2.29)115/1872.23 (1.28-3.89)
CYP1A1*2CGSTM10.78
02Non-null47/1501.00 (referent)80/1441.74 (1.13-2.69)
0Null59/179  1.04 (0.67-1.63)95/1382.15 (1.40-3.31)
≥ 1Non-null22/114  0.63 (0.36-1.11)51/981.59 (0.98-2.57)
≥ 1Null31/110  0.94 (0.55-1.58)70/1191.77 (1.13-2.78)
CYP1A1*2CGSTT10.11
02Non-null60/1511.00 (referent)94/1701.39 (0.93-2.07)
0Null46/178  0.66 (0.42-1.03)81/1121.80 (1.18-2.75)
≥ 1Non-null29/117  0.65 (0.39-1.09)75/1141.62 (1.06-2.48)
≥ 1Null24/107  0.59 (0.34-1.01)46/1031.06 (0.66-1.69)
CYP1A1*2CGSTM1 + GSTT10.22
020429/711.00 (referent)45/851.26 (0.71-2.23)
0149/159  0.73 (0.42-1.26)84/1441.41 (0.84-2.37)
02 (both null)28/99  0.69 (0.38-1.28)46/532.03 (1.12-3.69)
≥ 1010/63  0.39 (0.17-0.87)34/541.46 (0.79-2.72)
≥ 1131/105  0.75 (0.41-1.36)58/1041.31 (0.76-2.26)
≥ 12 (both null)12/56  0.53 (0.25-1.15)29/591.09 (0.58-2.05)
CYP1A1*2CNQO1 C609T0.34
02CC34/1271.00 (referent)68/932.64 (1.60-4.36)
0CT + TT72/202  1.33 (0.83-2.12)107/1892.10 (1.33-3.31)
≥ 1CC18/94  0.75 (0.39-1.41)41/981.41 (0.83-2.41)
≥ 1CT + TT35/130  1.03 (0.60-1.77)80/1192.47 (1.53-4.00)