Annexin A2 silencing inhibits invasion, migration, and tumorigenic potential of hepatoma cells

doi:10.3748/wjg.v19.i24.3792

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2013; 19(24): 3792-3801
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3792

Table 1 Expression level of ANXA2 mRNA in hepatocellular carcinoma cells and normal hepatic cells

Group	n	Ct_ANXA2	Ct_β-actin	2^-^ΔΔCt
LO2	5	25.16 ± 0.09	20.86 ± 0.03	1.00
HepG2	5	22.14 ± 0.15	20.66 ± 0.02	7.07 ± 0.35^b
SMMC-7402	5	22.87 ± 0.15	20.80 ± 0.14	4.68 ± 0.31^b
SMMC-7721	5	22.21 ± 0.12	20.72 ± 0.10	7.02 ± 0.19^b
MHCC97-H	5	21.85 ± 0.26	20.78 ± 0.13	9.45 ± 0.53^b

^bP < 0.001 vs the LO2 group.

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Table 2 Inhibition of ANXA2 mRNA expression by small hairpin in MHCC97-H cells

Group	n	Ct_ANXA2	Ct_β-actin	2^-^ΔΔCt
MHCC97-H	5	21.84 ± 0.11	20.77 ± 0.16	1.00
MHCC97-H/control-shRNA	5	21.83 ± 0.21	20.72 ± 0.10	0.97 ± 0.04
MHCC97-H/ANXA2-shRNA	5	24.24 ± 0.55	20.80 ± 0.14	0.20 ± 0.05^b

^bP < 0.001 vs the MHCC97-H group. shRNA: Small hairpin RNA.

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Table 3 Intensity of ANXA2 expression in xenograft tumours

Group	n	ANXA2 intensity				Z
		-	+	++	+++
MHCC97-H	4	0	0	0	4
MHCC97-H/control-shRNA	4	0	0	1	3	1.000
MHCC97-H/ANXA2-shRNA	4	1	3	0	0	2.530^a

^aP < 0.05 vs the MHCC97-H group. shRNA: Small hairpin RNA.

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Citation: Zhang HJ, Yao DF, Yao M, Huang H, Wang L, Yan MJ, Yan XD, Gu X, Wu W, Lu SL. Annexin A2 silencing inhibits invasion, migration, and tumorigenic potential of hepatoma cells. World J Gastroenterol 2013; 19(24): 3792-3801
URL: https://www.wjgnet.com/1007-9327/full/v19/i24/3792.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i24.3792