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World J Gastroenterol. May 21, 2013; 19(19): 2904-2912
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2904
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2904
Group 1 (control) | Group2 (GH) | Group 3 (HBOT) | Group 4 (GH + HBOT) | P1(Groups 1-2) | P2(Groups 1-3) | P3(Groups 1-4) | |
Histological findings of wound healing | |||||||
Epithelialization | 0.3 | 1.3 | 1.0 | 1.7 | > 0.05 | > 0.05 | < 0.01 |
Granulation | 2.4 | 1.4 | 1.9 | 1.1 | > 0.05 | > 0.05 | > 0.05 |
Fibroblast | 1.7 | 1.8 | 2.0 | 2.4 | > 0.05 | > 0.05 | < 0.05 |
Inflammation | 1.4 | 1.1 | 1.2 | 1.2 | > 0.05 | > 0.05 | > 0.05 |
Angiogenesis | 4.4 | 7.5 | 7.2 | 8.9 | < 0.01 | < 0.01 | < 0.01 |
Collagen deposition | 0.9 | 2.2 | 1.6 | 2.6 | < 0.01 | < 0.05 | < 0.01 |
Morphological and functional findings | |||||||
Villus density | 0.2 | 1.3 | 1.1 | 2.0 | < 0.01 | < 0.01 | < 0.01 |
Villus height (μm) | 101 (70-109) | 135 (98-153) | 118 (81-129) | 153 (119-181) | < 0.05 | > 0.05 | < 0.05 |
Crypt depth (μm) | 83 (74-88) | 102 (82-114) | 93 (76-101) | 120 (101-133) | > 0.05 | > 0.05 | < 0.05 |
Goblet cells | 0.2 | 1.4 | 1.1 | 2.2 | < 0.01 | < 0.01 | < 0.01 |
Mucin | 0.2 | 1.7 | 1.2 | 2.2 | < 0.01 | < 0.01 | < 0.01 |
Group 1 (control) | Group 2 (GH therapy) | Group 4 (GH + HBO therapy) | P1(Groups 1-2) | P2(Groups 1-4) | |
Before the surgery | |||||
IGF-1 (nmol/L) | 445 (402-482) | 421 (405-460) | 431 (395-470) | NS | NS |
IGFBP-3 (nmol/L) | 2250 (2100-2350) | 2170 (2000-2300) | 2147 (2025-2350) | NS | NS |
After the surgery (3 wk) | |||||
IGF-1 (nmol/L) | 445 (415-500) | 799 (755-875) | 813 (775-900) | < 0.05 | < 0.05 |
IGFBP-3 (nmol/L) | 2290 (2050-2500) | 3300 (3000-3600) | 3328 (3000-3650) | < 0.05 | < 0.05 |
P | NS | < 0.05 | < 0.05 |
- Citation: Adas G, Adas M, Arikan S, Sarvan AK, Toklu AS, Mert S, Barut G, Kamali S, Koc B, Tutal F. Effect of growth hormone, hyperbaric oxygen and combined therapy on the gastric serosa. World J Gastroenterol 2013; 19(19): 2904-2912
- URL: https://www.wjgnet.com/1007-9327/full/v19/i19/2904.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i19.2904