Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats

Table 1 Metabolic and hemodynamic parameters during pump infusion period in rats

	Pump infusion (wk)	CPV	FPV	FPV + LA	FPLPS	FPLPS + LA
Body weight (g)	4	349 ± 19	383 ± 8	351 ± 29	358 ± 6	371 ± 6
	8	451 ± 7	474 ± 8	445 ± 29	436 ± 11	423 ± 7
Glucose (mmol/L)	4	5.9 ± 0.3	5.9 ± 0.1	6.62 ± 1.2	6.08 ± 0.1	6.1 ± 0.1
	8	5.9 ± 0.2	6.4 ± 0.2	7.8 ± 0.7	6.76 ± 0.2	6.43 ± 0.1
Insulin (ng/mL)	4	0.5 ± 0.1	0.7 ± 0.1	0.7 ± 0.1	0.6 ± 0.1	0.6 ± 0.1
	8	0.6 ± 0.1	2.5 ± 0.6a	2.2 ± 0.3a	1.9 ± 0.5a	2.4 ± 0.4a
TG (mg/dL)	4	58 ± 4	180 ± 14a	185 ± 13a	185 ± 24a	163 ± 16a
	8	52 ± 4	324 ± 38a	286 ± 22a	308 ± 24a	249 ± 44a
AST (U/L)	4	65 ± 5	76 ± 1	82 ± 6	70 ± 2	77 ± 2
	8	58 ± 4	72 ± 2	73 ± 6	68 ± 2	70 ± 2
ALT (U/L)	4	53 ± 2	57 ± 1	56 ± 0	52 ± 1	51 ± 2
	8	56 ± 2	49 ± 1	44 ± 6	46 ± 1	51 ± 1
Albumin (mmol/L)	4	40 ± 1	35 ± 1	37 ± 1	35 ± 0	36 ± 0
	8	41 ± 1	35 ± 0	34 ± 1	35 ± 0	35 ± 0
CRP (μg/mL)	8	397 ± 10	504 ± 10a	555 ± 39	583 ± 13c	529 ± 22e
Amylase (U/L)	8	1278 ± 138	1750 ± 23a	1753 ± 58	2149 ± 31c	1744 ± 16e
Superoxide (count/min)	8	1337 ± 68	3169 ± 24a	3860 ± 52	6069 ± 60c	3234 ± 33e
WBC count (/mm3)	8	14168 ± 586	20290 ± 390a	22622 ± 630	24357 ± 1008c	21442 ± 767e
Plasma endotoxin (EU/mL)	8	< 0.02	< 0.02	< 0.02	< 0.02	< 0.02

Rats were on regular (C) or high-fructose enriched diet (F) for 4 wk and then further divided into those with intraportal infusion of saline or lipopolysaccharides (LPS), combined with vehicle or α lipoic acid (LA) for additional 4 wk (C_PV, F_PV, F_{PV + LA}, F_PLPS, F_{PLPS + LA}). Values are expressed as mean ± SE, n = 6 per group.

^aP < 0.05 vs C_PV;

^cP < 0.05 vs F_PV;

^eP < 0.05 vs F_PLPS for each corresponding time point. TG: Triglycerides; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; CRP: C-reactive protein; WBC: White blood cell.