Exposure to gastric juice may not cause adenocarcinogenesis of the esophagus

Table 1 Intraluminal pH and bile positive in the forestomach between the time of esophagoduodenostomy and 40 wk after esophagoduodenostomy

	Model (n = 25)		Control (n = 29)
	pH (mean ± SD)	Bile positive (n)	pH (mean ± SD)	Bile positive (n)
At the time of esophagoduodenostomy	3.22 ± 0.29	2	3.23 ± 0.29	3
40 wk after esophagoduodenostomy	3.24 ± 0.31	2	3.25 ± 0.25	4

Table 2 Incidence of inflammation, intestinal metaplasia, intestinal metaplasia with dysplasia, and adenocarcinoma in the esophagus and forestomach 40 wk after surgery n (%)

	Inflammation	Intestinal metaplasia	Intestinal metaplasia with dysplasia	Adenocarcinoma
Control esophagus (n = 29)	2 (6.8)	1 (3.4)	0	0
Model esophagus (n = 25)	24 (96)	22 (88)	5 (20)	2 (8)
Control forestomach (n = 29)	2 (6.8)	1 (3.4)	0	0
Model forestomach (n = 25)	25 (100)	2 (8)	0	0