Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma

Table 1 Correlation of CD73 and hypoxia-inducible factor-1α expression with clinicopathological characteristics of gastric carcinoma

Clinicopathological data	CD73 expression		P value	HIF-1αexpression		P value
	High	Low		High	Low
Gender			0.144			0.136
Male	18	25		21	22
Female	13	12		15	10
Age (yr)			0.157			0.107
< 49.82	10	15		11	14
≥ 49.82	21	22		25	18
Tumor diameter (cm)			0.127			0.031
≤ 5	7	17		9	15
5-10	10	5		8	7
> 10	14	15		19	10
Differentiation			0.000			0.445
Well	1	4		4	1
Moderate	6	22		13	15
Poor	24	11		19	16
Histopathology			0.041			0.168
Tubular adenocarcinoma	3	16		7	12
Poorly differentiated adenocarcinoma	21	11		21	11
Signet-ring cell carcinoma	3	3		2	4
Mucinous adenocarcinoma	4	7		6	5
Borrmann type			0.140			0.430
I	5	19		9	16
II	9	12		9	12
III	15	13		17	11
IV	2	2		1	3
Depth of invasion			0.000			0.036
T1-T2	1	21		8	14
T3-T4	30	16		28	18
Nodal status			0.003			0.113
N0	4	17		9	12
N1/N2	27	20		27	20
Metastasis			0.013			0.192
M0	20	33		27	26
M1	11	4		9	6
AJCC stage			0.000			0.035
I/II	2	24		10	16
III/IV	27	15		26	16

HIF-1α: Hypoxia-inducible factor-1α; AJCC: American Joint Committee on Cancer.