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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 21, 2013; 19(11): 1718-1727
Published online Mar 21, 2013. doi: 10.3748/wjg.v19.i11.1718
Published online Mar 21, 2013. doi: 10.3748/wjg.v19.i11.1718
Table 1 CpG islands hypermethylation of tumor-associated genes in pancreatic fluids
| Age (yr) | Sex | Stage | UCHL1 | RUNX3 | CDKN2A | IGF2 | CACNA1G | AHRR | SFRP1 | MGMT | APC | NEUROG1 | |
| NC1 | 68 | M | MN | MN | MN | MN | MN | MN | MP | MP | MN | MN | |
| NC2 | 65 | M | MN | MN | MN | MN | MP | MN | MN | MN | MN | MN | |
| NC3 | 59 | M | MN | MN | MP | MN | MN | MN | MN | MN | MN | MP | |
| NC4 | 70 | F | MN | MN | MN | MP | MN | MN | MN | MN | MN | MN | |
| NC5 | 43 | F | MN | MN | MN | MN | MN | MN | MN | MP | MN | MN | |
| NC6 | 55 | M | MN | MN | MN | MN | MP | MN | MN | MN | MN | MN | |
| NC7 | 49 | M | MN | MN | MN | MN | MN | MP | MN | MN | MP | MN | |
| MN | MN | MN | MN | MN | MN | MN | MN | MN | MN | ||||
| IP1 | 71 | F | MN | MN | MP | MN | MN | MN | MN | MN | MN | MN | |
| IP2 | 79 | F | MN | MN | MN | MN | MN | MN | MN | MN | MN | MP | |
| IP3 | 76 | M | MN | MP | MN | MN | MN | MN | MN | MP | MN | MN | |
| IP4 | 75 | F | MN | MN | MN | MP | MN | MP | MP | MN | MP | MN | |
| IP5 | 84 | F | MN | MN | MN | MN | MN | MN | MP | MN | MN | MN | |
| IP6 | 52 | M | MN | MN | MP | MN | MN | MN | MP | MP | MN | MN | |
| IP7 | 62 | M | MN | MN | MN | MP | MN | MN | MN | MP | MP | MN | |
| IP8 | 63 | M | MN | MN | MP | MN | MN | MN | MN | MP | MN | MN | |
| MN | MN | MN | MN | MN | MN | MN | MN | MN | MN | ||||
| PC1 | 66 | F | IIA | MP | MN | MN | MN | MN | MN | MN | MP | MN | MN |
| PC2 | 54 | F | III | MN | MP | MN | MN | MN | MN | MN | MN | MN | MN |
| PC3 | 66 | M | IIB | MP | MP | MN | MN | MN | MN | MP | MN | MP | MP |
| PC4 | 67 | M | IIB | MP | MN | MN | MN | MP | MN | MN | MN | MP | MN |
| PC5 | 71 | M | IIB | MN | MP | MP | MN | MN | MN | MN | MN | MN | MN |
| PC6 | 49 | F | IIA | MP | MP | MN | MN | MN | MN | MP | MN | MP | MP |
| PC7 | 73 | F | IIB | MP | MN | MN | MN | MN | MP | MP | MN | MN | MN |
| PC8 | 75 | M | III | MP | MP | MN | MN | MN | MN | MN | MN | MP | MN |
| PC9 | 59 | M | IIB | MN | MN | MN | MN | MP | MN | MP | MP | MP | MP |
| PC10 | 78 | F | IIA | MP | MP | MP | MN | MN | MN | MP | MP | MN | MP |
| PC11 | 75 | F | IIB | MN | MN | MN | MP | MN | MN | MP | MN | MN | MN |
| PC12 | 66 | M | IV | MP | MP | MP | MN | MN | MN | MP | MN | MP | MP |
| PC13 | 70 | F | IV | MP | MN | MN | MN | MN | MP | MP | MP | MP | MP |
| PC14 | 68 | M | IB | MN | MP | MN | MN | MN | MN | MN | MP | MN | MN |
| PC15 | 62 | M | IIB | MP | MN | MP | MN | MN | MN | MN | MN | MN | MN |
Table 2 CpG islands hypermethylation of tumor-associated genes in biliary fluids
| Age (yr) | Sex | Stage | UCHL1 | RUNX3 | CDKN2A | IGF2 | CACNA1G | AHRR | SFRP1 | MGMT | APC | NEUROG1 | |
| NC8 | 77 | M | MN | MN | MN | MN | MN | MN | MN | MP | MN | MN | |
| NC9 | 69 | F | MN | MN | MN | MN | MN | MN | MP | MN | MN | MN | |
| NC10 | 76 | M | MN | MN | MN | MN | MN | MN | MN | MP | MN | MN | |
| NC11 | 58 | M | MN | MN | MN | MN | MN | MN | MN | MN | MN | MN | |
| NC12 | 41 | M | MN | MN | MN | MN | MN | MP | MN | MP | MN | MN | |
| NC13 | 66 | M | MN | MN | MN | MN | MN | MP | MP | MP | MP | MP | |
| NC14 | 69 | F | MN | MN | MN | MN | MN | MP | MP | MP | MN | MP | |
| NC15 | 71 | F | MN | MN | MN | MN | MN | MN | MN | MP | MP | MN | |
| NC16 | 59 | M | MN | MN | MN | MN | MN | MP | MP | MN | MN | MN | |
| NC17 | 54 | F | MN | MN | MN | MN | MN | MN | MN | MN | MP | MP | |
| NC18 | 67 | M | MN | MN | MN | MN | MN | MP | MP | MN | MN | MN | |
| NC19 | 85 | M | MN | MN | MN | MN | MN | MN | MN | MN | MN | MN | |
| NC20 | 73 | F | MN | MN | MN | MN | MN | MN | MP | MN | MN | MN | |
| NC21 | 80 | F | MN | MN | MN | MN | MN | MN | MN | MP | MN | MN | |
| NC22 | 74 | F | MN | MN | MN | MN | MN | MN | MN | MP | MN | MN | |
| NC23 | 52 | M | MN | MN | MN | MN | MN | MN | MN | MN | MN | MN | |
| NC24 | 64 | M | MN | MN | MN | MN | MN | MN | MP | MP | MP | MN | |
| NC25 | 64 | F | MN | MN | MN | MN | MN | MP | MP | MN | MN | MN | |
| MN | MN | MN | MN | MN | MN | MN | MN | MN | MN | ||||
| GB1 | 75 | F | IIIB | MP | MP | MP | MP | MP | MP | MN | MN | MN | MN |
| GB | 76 | F | IIIB | MN | MP | MP | MP | MP | MP | MN | MN | MP | MN |
| GB3 | 62 | M | IIIA | MP | MP | MP | MP | MN | MN | MP | MP | MN | MN |
| GB4 | 67 | M | IVA | MN | MP | MN | MN | MN | MN | MN | MN | MN | MN |
| GB5 | 59 | F | IIIB | MP | MN | MP | MN | MN | MP | MP | MN | MP | MP |
| GB6 | 63 | F | II | MP | MN | MP | MN | MN | MP | MP | MN | MP | MP |
| GB7 | 77 | M | I | MN | MP | MP | MN | MN | MN | MP | MP | MN | MN |
| GB8 | 78 | M | IIIA | MP | MN | MP | MN | MN | MN | MP | MP | MN | MN |
| BC1 | 73 | M | I | MN | MP | MN | MP | MN | MP | MP | MN | MN | MN |
| BC2 | 80 | F | IIA | MP | MP | MN | MN | MN | MP | MP | MP | MN | MN |
| BC3 | 71 | M | IIB | MP | MN | MN | MN | MP | MP | MP | MN | MN | MN |
| BC4 | 75 | M | III | MP | MN | MN | MN | MN | MN | MP | MP | MN | MN |
| BC5 | 77 | M | IIB | MN | MP | MN | MN | MN | MN | MN | MP | MN | MN |
| BC6 | 65 | M | IIA | MP | MN | MP | MN | MN | MN | MN | MN | MN | MN |
| BC7 | 72 | M | IIA | MP | MN | MN | MN | MN | MN | MP | MN | MN | MN |
| BC8 | 73 | F | IV | MP | MP | MN | MN | MN | MP | MN | MN | MN | MN |
| BC9 | 76 | F | IIA | MP | MP | MN | MP | MP | MP | MP | MN | MN | MN |
| BC10 | 74 | M | IIB | MP | MN | MN | MN | MN | MP | MN | MP | MN | MP |
| BC11 | 66 | M | III | MP | MN | MN | MN | MN | MN | MN | MN | MP | MN |
| BC12 | 58 | F | IIB | MN | MP | MN | MN | MN | MN | MN | MN | MN | MN |
| PC1 | 66 | F | IIA | MP | MN | MN | MN | MN | MN | MP | MP | MN | MN |
| PC5 | 71 | M | IIB | MN | MP | MP | MN | MN | MN | MN | MP | MN | MN |
| PC7 | 73 | F | IIB | MP | MN | MN | MN | MN | MP | MN | MN | MN | MN |
| PC8 | 75 | M | III | MP | MP | MN | MN | MN | MN | MN | MP | MN | MN |
| PC13 | 70 | F | IV | MP | MN | MN | MN | MN | MP | MP | MP | MP | MN |
| PC16 | 59 | M | IIA | MP | MP | MN | MN | MP | MN | MN | MN | MN | MN |
| PC17 | 80 | F | IIB | MP | MP | MP | MP | MN | MP | MP | MN | MN | MN |
| PC18 | 67 | M | IB | MN | MP | MN | MN | MN | MP | MN | MP | MN | MN |
| PC19 | 63 | M | IIA | MP | MN | MN | MN | MN | MN | MN | MP | MP | MN |
| PC20 | 78 | F | IIB | MN | MN | MP | MN | MN | MP | MN | MN | MN | MN |
- Citation: Kato N, Yamamoto H, Adachi Y, Ohashi H, Taniguchi H, Suzuki H, Nakazawa M, Kaneto H, Sasaki S, Imai K, Shinomura Y. Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids. World J Gastroenterol 2013; 19(11): 1718-1727
- URL: https://www.wjgnet.com/1007-9327/full/v19/i11/1718.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i11.1718
