Rates and impact of hepatitis on human immunodeficiency virus infection in a large African cohort

doi:10.3748/wjg.v19.i10.1602

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2013; 19(10): 1602-1610
Published online Mar 14, 2013. doi: 10.3748/wjg.v19.i10.1602

Table 1 Baseline characteristics by hepatitis status of patients at Jos University Teaching Hospital, 2004-2010 n (%)

Characteristic	Total	HBV	HCV	Triple infection	HIV only
Gender
Male	6222 (34.8)	1214 (38.1)^b	764 (37.9)^b	178 (39.3)^b	4066 (33.2)
Female	11 660 (65.2)	1971 (61.9)^b	1250 (62.1)^b	275 (60.7)^b	8164 (66.8)
Age group (yr)
15-29	5870 (32.8)	1097 (34.4)^b	463 (23.0)^b	120 (26.5)	4190 (34.3)
30-39	7106 (39.7)	1309 (41.1)^b	786 (39.0)^b	206 (45.5)	4805 (39.4)
40-49	3619 (20.2)	615 (19.3)^b	533 (26.5)^b	94 (20.8)	2377 (19.5)
≥ 50	1287 (7.2)	164 (5.1)^b	232 (11.5)^b	33 (7.3)	828 (6.8)
Tuberculosis diagnosis
Present	2552 (14.3)	470 (14.8)	300 (14.9)	68 (15.0)	1714 (14.0)
Absent	15 330 (85.7)	2715 (85.2)	1714 (85.0)	385 (85.0)	10516 (86.0)
Education status
None	3230 (18.8)	527 (17.2)	471 (24.3)	87 (19.8)	2145 (18.3)
Primary	3487 (20.3)	623 (20.3)	440 (22.7)	96 (21.8)	2328 (19.9)
Secondary	5208 (30.4)	962 (31.4)	536 (27.6)	146 (33.2)	3564 (30.5)
Tertiary	5219 (30.4)	954 (31.1)	494 (25.4)	111 (25.2)	3660 (31.3)
CD4 (cells/mm³)
< 200	2937 (50.7)	645 (55.4)^b	343 (52.5)	97 (56.7)^b	1852 (48.6)
200-499	2214 (38.2)	410 (35.3)^b	249 (38.1)	57 (33.3)^b	1498 (39.3)
≥ 500	646 (11.1)	108 (9.3)^b	61 (9.3)	17 (9.9)^b	460 (12.1)
HIV (copies/mL)
Undetect (< 400)	2194 (12.4)	351 (11.2)^b	221 (11.1)^b	29 (6.7)^b	1583 (13.1)
Low (400-9999)	3581 (20.3)	562 (17.9)^b	364 (18.2)^b	99 (22.8)^b	2556 (21.1)
Interm (10 000-29 999)	2774 (15.7)	523 (16.7)^b	321 (16.1)^b	72 (16.6)^b	1858 (15.4)
High (≥ 30 000)	9115 (51.6)	1700 (54.2)^b	1090 (53.9)^b	234 (53.9)^b	6091 (50.4)

^bP < 0.01 vs human immunodeficiency virus (HIV) only; Undetect: Undetectable; Interm: Intermediate; HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Table 2 Outcome on antiretroviral therapy for at least 12 mo of hepatitis status of human immunodeficiency virus infected individuals at Jos University Teaching Hospital, 2004-2010 n (%)

Variable	Total	HBV	HCV	Both	HIV only
CD4 (cells/mm³)				†
< 200	2028 (18.5)	396 (21.3)^b	218 (17.5)	50 (20.2)^b	1364 (17.9)
200-499	5549 (50.7)	953 (51.3)^b	625 (50.3)	129 (52.2)^b	3842 (50.6)
≥ 500	3369 (30.8)	508 (27.4)^b	400 (32.2)	68 (27.5)^b	2393 (31.4)
HIV RNA (copies/mL)
Undetectable (< 400)	7155 (65.4)	1186 (63.9)	809 (65.1)	155 (62.8)	5005 (65.9)
Detectable (≥ 400)	3792 (34.6)	671 (36.1)	434 (34.9)	92 (37.2)	2595 (34.1)
Liver disease
Present	31 (2.8)	8 (4.3)	4 (3.2)	0 (0.0)	19 (2.5)
None diagnosed	10 916 (97.2)	1849 (95.7)	1239 (96.8)	247 (100)	7581 (97.5)

^bP < 0.01 vs human immunodeficiency virus (HIV) only. HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Citation: Ladep NG, Agaba PA, Agbaji O, Muazu A, Ugoagwu P, Imade G, Cooke G, McCormack S, Taylor-Robinson SD, Idoko J, Kanki P. Rates and impact of hepatitis on human immunodeficiency virus infection in a large African cohort. World J Gastroenterol 2013; 19(10): 1602-1610
URL: https://www.wjgnet.com/1007-9327/full/v19/i10/1602.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i10.1602