Scolopendra subspinipes mutilans protected the cerulein-induced acute pancreatitis by inhibiting high-mobility group box protein-1

Table 1 Effect of Scolopendra subspinipes mutilans water extract on pancreatic histological scoring during acute pancreatitis (mean ± SE, n = 6)

Group	Edema	Inflammation	Vacuolization	Necrosis
Saline	0.1 ± 0.02	0.3 ± 0.05	0.1 ± 0.03	0.2 ± 0.02
AP	2.6 ± 0.03a	2.8 ± 0.04a	2.4 ± 0.02a	2.5 ± 0.05a
SSM 0.1 + AP	2.3 ± 0.05ac	2.0 ± 0.02ac	1.6 ± 0.04ac	1.8 ± 0.01ac
SSM 0.5 + AP	1.0 ± 0.02ac	1.5 ± 0.05ac	1.2 ± 0.02ac	1.5 ± 0.04ac
SSM 1 + AP	0.6 ± 0.01ac	1.0 ± 0.03ac	0.7 ± 0.05ac	0.9 ± 0.03ac

The results were similar in 3 further experiments.

^aP < 0.05 vs control group;

^cP < 0.05 vs cerulein treatment alone. SSM: Scolopendra subspinipes mutilans; AP: Acute pancreatitis.

Table 2 Effect of Scolopendra subspinipes mutilans on lung histological scoring during acute pancreatitis (mean ± SE, n = 6)

Group	Edema	Inflammation
Saline	0.2 ± 0.05	0.3 ± 0.03
AP	2.7 ± 0.02a	2.8 ± 0.05a
SSM 0.1 + AP	2.2 ± 0.04ac	2.3 ± 0.02ac
SSM 0.5 + AP	1.6 ± 0.03 ac	1.5 ± 0.04ac
SSM 1 + AP	1.0 ± 0.05ac	0.8 ± 0.03ac

The results were similar in 3 further experiments.

^aP < 0.05 vs control group,

^cP < 0.05 vs cerulein treatment alone. SSM: Scolopendra subspinipes mutilans; AP: Acute pancreatitis.