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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 7, 2013; 19(1): 49-56
Published online Jan 7, 2013. doi: 10.3748/wjg.v19.i1.49
Published online Jan 7, 2013. doi: 10.3748/wjg.v19.i1.49
Table 1 Patients demographics, and their biochemical and histological data at liver biopsy examination (%)
Characteristics | All patients (n = 246) | HCV patients (n = 195) | HBV patients (n = 41) |
Sex (men) | 171 (69.5) | 139 (71.3) | 30 (73.2) |
Age (yr) | 44.7 (11.8)1 | 45.3 (11.5)1 | 41.2 (13.7)1 |
BMI (kg/m2) | 25.2 (3.9)1 | 25.3 (3.6)1 | 25.2 (5.3)1 |
AST (IU/L) | 39 (24-78)2 | 40 (26-80)2 | 28 (21-48)2 |
ALT (IU/L) | 65 (32-116)2 | 70 (35-120)2 | 50 (23-109)2 |
Platelets count (103/mm3) | 209 (171-262)2 | 212 (176-270)2 | 203 (172-253)2 |
Fibrosis score (Metavir) | |||
F0-F1 | 129 (52.3) | 98 (50.3) | 30 (73.2) |
F2 | 54 (22.0) | 46 (23.6) | 6 (14.6) |
F3 | 24 (9.8) | 19 (9.7) | 3 (7.3) |
F4 | 39 (15.9) | 32 (16.4) | 2 (4.9) |
Steatosis | |||
S0 (0%) | 157 (63.8) | 126 (64.6) | 26 (63.4) |
S1 (< 33%) | 56 (22.8) | 44 (22.6) | 10 (24.4) |
S2 (33%-66%) | 19 (7.7) | 15 (7.7) | 4 (9.8) |
S3 (> 66%) | 14 (5.7) | 10 (5.1) | 1 (2.4) |
HAI | |||
Mild | 109 (44.3) | 80 (41.0) | 28 (68.3) |
Moderate | 102 (41.5) | 89 (45.7) | 7 (17.1) |
Severe | 35 (14.2) | 26 (13.3) | 6 (14.6) |
Table 2 Cut-off values of transient elastography obtained by receiver operating characteristic curve analysis for each Metavir fibrosis stage
Sensitivity% | Specificity% | PPV% | NPV% | LR+ | LR- | AUC | |
F≥ 21 | |||||||
7.0 kPa | 70 (66-75) | 81 (77-85) | |||||
F≥ 22 | |||||||
6.9 kPa | 70.9 (61.8-79.0) | 86.1 (78.8-91.5) | 82.2 (73.3-89.1) | 76.6 (68.8-83.2) | 5.1 (4.4-5.8) | 0.34 (0.2-0.6) | 0.86 (0.81-0.90) |
F≥ 23 | |||||||
6.9 kPa | 69.1 (58.9-78.1) | 89.8 (82.0-95.0) | 87.0 (77.4-93.6) | 74.6 (65.7-82.1) | 6.8 (5.8-7.9) | 0.34 (0.2-0.7) | 0.86 (0.80-0.90) |
F≥ 31 | |||||||
9.5 kPa | 80 (72-85) | 85 (79-90) | |||||
F≥ 32 | |||||||
7.9 kPa | 88.9 (78.4-95.4) | 85.8 (79.9-90.5) | 68.3 (57.1-78.1) | 95.7 (91.4-98.3) | 6.3 (5.6-7.0) | 0.13 (0.06-0.3) | 0.94 (0.91-0.97) |
9.6 kPa4 | 76.3 (73.8-86.9) | 94.5 (90.2-97.3) | 82.8 (70.6-91.4) | 92.0 (87.2-95.5) | 13.9 (12.1-16.1) | 0.25 (0.1-0.5) | |
F≥ 33 | |||||||
7.3 kPa | 94.1 (83.8-98.8) | 85.4 (70.6-90.7) | 69.6 (57.3-80.1) | 97.6 (93.2-99.4) | 6.5 (5.9-7.1) | 0.07 (0.02-0.2) | 0.95 (0.91-0.98) |
9.3 kPa4 | 74.5 (60.4-85.7) | 96.5 (92.1-98.9) | 88.4 (74.9-96.1) | 91.4 (85.8-95.4) | 21.5 (18.2-25.3) | 0.3 (0.1-0.7) | |
F = 41 | |||||||
12 kPa | 86 (80-91) | 88 (82-91) | |||||
F = 42 | |||||||
9.6 kPa | 95 (83-99) | 90 (85-94) | 64 (50-76) | 99 (96-100) | 9.4 (8.6-10.2) | 0.06 (0.01-0.2) | 0.96 (0.93-0.98) |
12.2 kPa4 | 84.6 (69.5-94.1) | 94.7 (90.7-97.3) | 75.0 (59.7-86.8) | 97.0 (93.6-98.9) | 15.9 (13.9-18.3) | 0.16 (0.06-0.4) | |
F = 43 | |||||||
9.3 kPa | 93.8 (79.2-99.2) | 92.0 (86.7-95.7) | 69.0 (53.9-82.8) | 98.7 (93.3-99.8) | 11.8 (10.6-13.0) | 0.07 (0.02-0.3) | 0.97 (0.93-0.99) |
12.3 kPa4 | 81.3 (63.6-92.8) | 95.7 (91.4-98.3) | 78.8 (61.1-91.0) | 96.3 (92.1-98.6) | 18.9 (16.0-22.4) | 0.2 (0.07-0.5) |
- Citation: Ferraioli G, Tinelli C, Dal Bello B, Zicchetti M, Lissandrin R, Filice G, Filice C, Above E, Barbarini G, Brunetti E, Calderon W, Di Gregorio M, Gulminetti R, Lanzarini P, Ludovisi S, Maiocchi L, Malfitano A, Michelone G, Minoli L, Mondelli M, Novati S, Patruno SF, Perretti A, Poma G, Sacchi P, Zanaboni D, Zaramella M. Performance of liver stiffness measurements by transient elastography in chronic hepatitis. World J Gastroenterol 2013; 19(1): 49-56
- URL: https://www.wjgnet.com/1007-9327/full/v19/i1/49.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i1.49