Nestin: A novel angiogenesis marker and possible target for tumor angiogenesis

Table 1 Angiogenesis markers for analysis of microvessel density

	Factor VIII	CD 31	CD 34	Nestin
Roles	Glycoprotein	Glycoprotein	Glycoprotein	Cytoskeletal protein
	Blood coagulation	Endothelial cell intercellular junctions[57], migration	Cell-cell adhesion factor, facilitate opening of vascular lumens[58]	Cell cycle[22,59], migration
Character of positive vessels	Large size	Small to large size	Small to large size	Small size[27]
	Mature vessels	Immature to mature vessels	Immature to mature vessels	Immature vessels[26,30]
				High-proliferating activity[26,27]
Clinical outcome
Esophageal cancer	Poor prognosis[60]	Poor prognosis[61,62]	Poor prognosis[63,64]	-
Gastric cancer	Advanced stage[65]	No relation[66]	No relation[45]	No relation[44]
Colorectal cancer	No relation[68]	Poor prognosis[68]	Poor prognosis[67]	Poor prognosis[42]
	Liver metastasis[69]		Poor prognosis[68]
Liver cancer	No relation[70]		Liver metastasis[69]
Pancreatic cancer	Poor prognosis[16]	No relation[71]	Poor prognosis[70,72-75]
		Lymph node meta[76]	No relation[28]	No relation[27]
			Poor prognosis[77,78]
Prostate cancer	Poor prognosis[79-81]	No relation[82]	Poor prognosis[83]	Poor prognosis[26]
Glioblastoma	Tumor grade[84]	No relation[85]	No relation[86]	Tumor grade[45]