Prealbumin is predictive for postoperative liver insufficiency in patients undergoing liver resection

Table 1 Baseline characteristics of all 427 patients

Variables	n = 427
Sex (male/female)	362/65
Age (yr)	51.1 ± 10.4
Surgical indications
HCC	391
ICC	31
HCC-ICC1	5
Tumor size (cm)	6.2 ± 4.0
WBC (× 109/L)	5.5 ± 1.8
PLT (× 109/L)	160.5 ± 66.4
PT (s)	12.2 ± 4.8
Total bilirubin (μmol/L)	14.6 ± 5.8
Albumin (g/L)	42.0 ± 4.0
Prealbumin (mg/dL)	217.6 ± 61.0
ALT (IU/L)	47.4 ± 43.7
Hepatitis virus background
HBV	362
HCV	4
HBV-HCV2	3
None	58
Liver cirrhosis
Yes	234
No	193
Ascites
Little	48
No	378
Esophageal varices
Present	60
Absent	367
Types of liver resection
Minor ≤ 3 liver segments	358
Major ≥ 4 liver segments	69
Inflow blood occlusion time (min)	15.8 ± 8.0
Blood loss (mL)	200 (50, 5500)
Blood transfusion (yes/no)	43/384

¹Concurrence of HCC and ICC;

²Concurrence of HBV and HCV. HCC: Hepatocellular carcinoma; ICC: Intrahepatic cholangiocarcinoma; WBC: White blood cell; PLT: Platelet; PT: Prothrombin time; ALT: Alanine aminotransferase; HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Table 2 Univariate analysis of factors related to postoperative liver insufficiency

Variables	Patients with liver insufficiency(n = 17)	Patients without liver insufficiency(n = 410)	P value
Sex (male/female)	17/0	345/65	0.075
Age (yr)	57.6 ± 7.1	50.8 ± 10.4	0.008
< 60	10	325
≥ 60	7	85
Tumor size (cm)	6.6 ± 5.0	6.2 ± 3.9	0.664
≥ 10	4	79
< 10	13	331
WBC (× 109/L)	5.2 ± 1.9	5.5 ± 1.8	0.581
PLT(× 109/L)	146.0 ± 88.2	161.1 ± 65.4	0.357
PT (s)	12.5 ± 1.3	12.2 ± 4.9	0.816
Total bilirubin (μmol/L)	16.3 ± 5.7	14.5 ± 5.8	0.205
Albumin (g/L)	40.2 ± 4.3	42.0 ± 4.3	0.074
Prealbumin (mg/dL)	191.4 ± 59.6	217.9 ± 61.1	0.049
< 170	8	84
≥ 170	9	326
ALT (IU/L)	52.2 ± 38.0	47.2 ± 43.9	0.647
≥ 100	3	29
< 100	14	381
Viral background			0.222
HBV and/or HCV	4	54
None	13	356
Liver cirrhosis			0.182
No	5	188
Yes	12	222
Ascites			0.415
Little	3	46
No	14	364
Esophageal varices			0.251
Present	4	56
Absent	13	354
Types of liver resection			0.130
Minor ≤ 3 liver segments	12	346
Major ≥ 4 liver segments	5	64
Inflow blood occlusion time (min)	17.2 ± 6.2	15.7 ± 8.0	0.438
> 20	4	102
≤ 20	13	308
Blood loss (mL)	200 (50-5500)	200 (50-2800)	0.362
≥ 800	1	36
< 800	16	374
Blood transfusion			0.558
Yes	1	42
No	16	368

WBC: White blood cell; PLT: Platelet; PT: Prothrombin time; ALT: Alanine aminotransferase; HBV: Hepatitis B virus; HCV: Hepatitis C virus.