-449 C>G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility to ulcerative colitis

Table 1 Characteristics of the subjects and allelic frequency

	Controls	UC cases	P value
Number of sample	465	174
Age (mean ± SD)	50.6 ± 17.3	40.3 ± 13.9	< 0.0001
(age of onset)		(33.0 ± 13.4)
Male:female	253:212	98:76	NS
rs72696119 C>G
C/C	197	68
C/G	225	78
G/G	43	28	0.017
G allele frequency	33.40%	38.50%	0.10

UC: Ulcerative colitis; NS: Not significant.

Table 2 Association between rs72696119 and ulcerative colitis

	Genotype (n)			GG vs others
Overall	C/C	C/G	G/G	OR (95%CI)	P value
Controls (465)	197	225	43	Ref.	-
UC cases (174)	68	78	28	1.88 (1.13-3.14)	0.017
Male
Controls (253)	102	136	15	Ref.	-
UC cases (98)	40	42	16	3.10 (1.47-6.54)	0.0053
Female
Controls (212)	95	89	28	Ref.	-
UC cases (76)	28	36	12	1.23 (0.592-2.57)	0.57

UC: Ulcerative colitis; OR: Odds ratio.

Table 3 Association between rs72696119 and phenotype of ulcerative colitis

	Genotype (n)			GG vs others
	CC	CG	GG	OR (95%CI)	P value
Controls (465)	197	225	43	Ref.	-
Age of onset
≤ 20 (27)	12	9	6	2.80 (1.07-7.32)	0.041
21 ≤ (133)	50	66	17	1.44 (0.791-2.62)	0.25
Clinical type
Not continuous (98)	34	47	17	2.06 (1.13-3.77)	0.029
Continuous (71)	32	30	9	1.43 (0.662-3.07)	0.39
Extension
Not total colitis (93)	31	46	16	2.04 (1.09-3.80)	0.040
Total colitis (78)	35	32	11	1.61 (0.792-3.28)	0.22
Max UCDAI score
≤ 8 (60)	20	28	12	2.45 (1.23-4.93)	0.022
9 ≤ (106)	44	49	13	1.37 (0.716-2.63)	0.37
Hospitalization
None (106)	41	45	20	2.28 (1.29-4.05)	0.0090
One time ≤ (60)	25	30	5	0.892 (0.350-2.28)	1.00
Response to treatment
Steroid-dependent (34)	13	17	4	1.31 (0.440-3.89)	0.54
Steroid-refractory (46)	18	23	5	1.20 (0.449-3.19)	0.79

OR: Odds ratio.