Endoscopic findings in patients with Schatzki rings: Evidence for an association with eosinophilic esophagitis

Table 1 Demographic and clinical characteristics of all enrolled patients with Schatzki rings n (%)

Variables	Schatzki ring (n = 116)
Age, yr (mean ± SD)	55.2 ± 4.9
Gender (M/F)	84/32
History of allergy	34 (29)
Dysphagia	47 (41)
History of food impaction	9 (8)
Heartburn	31 (27)
No symptoms of esophageal dysfunction	31 (27)

M/F: Male/female.

Table 2 Histopathological features

Patient ID	Age (yr)	Gender	Met the clinical criteria of EoE	Eosinophils/hpf	Further histological findings suspicious of EoE
1	35	M	Yes	25	H
2	57	M	Yes	25	S
3	37	M	Yes	40	H
4	34	M	Yes	60	M1, S, H
5	31	F	Yes	20	None
6	43	M	Yes	50	H
7	44	M	Yes	45	S, H
8	43	F	Yes	45	S, H, F
9	48	M	Yes	55	S, H, F
10	23	F	Yes	35	H
11	35	M	Yes	60	H
12	60	M	No	20	S, H
13	44	M	No	20	H
14	46	M	No	25	S, H, F
15	47	M	No	60	H
16	39	M	No	45	H
17	29	M	No	45	H
18	35	M	No	60	S, H
19	39	M	No	25	H
20	39	F	No	30	H

Histopathological features of the 20 patients with a SR and hypereosinophilia (≥ 20 eosinophils/hpf) in the biopsy specimen of the esophagus. M: Male; F: Female; EoE: Eosinophilic esophagitis; F: Fibrosis of lamina propria; H: Epithelial hyperplasia; M1: Microabscess; S: Superficial layering of eosinophils; hpf: High power field.

Table 3 Baseline characteristics

Patient ID	Age (yr)	Gender	Dysphagia	History of food impaction	History of allergy	Endoscopic findings suspicious of EoE
1	35	M	+	-	+	Furrows
2	57	M	+	-	+	None
3	37	M	+	+	-	Trachealization
4	34	M	-	+	+	Furrows, trachealization
5	31	F	+	+	+	Furrows
6	43	M	+	-	-	Whitish exudates
7	44	M	+	-	+	None
8	43	F	+	-	+	None
9	48	M	+	-	+	Furrows
10	23	F	+	-	+	Furrows
11	35	M	+	+	-	Furrows

Baseline characteristics of the 11 patients with a Schatzki ring and eosinophilic esophagitis (EoE). M: Male; F: Female.

Table 4 Demographics, clinical and endoscopic findings n (%)

Variable	SR with EoE(n = 11)	SR without EoE (n = 105)	P value
Age (yr, mean ± SD)	41.5 ± 6.5	50.5 ± 11.5	0.012
Gender (M/F)	8/3	76/29	1.0
History of allergy	8 (72.7)	24 (29)	0.007
Dysphagia	10 (90.9)	36 (34.3)	0.004
History of food impaction	4 (36.4)	6 (5.7)	0.007
Heartburn	3 (27.3)	28 (26.7)	1.0
Ring narrow	4 (36.4)	19 (18.1)	0.22
Webs	4 (36.4)	12 (11.4)	0.044

Demographics and clinical and endoscopic findings for patients with a Schatzki ring (SR) with and without eosinophilic esophagitis (EoE). M: Male; F: Female.