Hepatic expression and cellular distribution of the glucose transporter family

Table 1 Summary of reported hepatic expression of glucose transporters isoforms

Class	GLUT isoform	Hepatic expression	Subcellular expression/localisation	Protein/mRNA	Ref.
Class I	GLUT1	Yes	Sinusoidal membrane of hepatocytes, protein restricted to hepatocytes proximal to the hepatic venule, also expressed on endothelial cells, kupffer cells and cholangiocytes; hepatocyte expression in HCC	Both	[110,113,115,116,120]
	GLUT2	Yes	Hepatocytes	Protein	[124-126]
	GLUT3	Yes	Hepatocytes, bile canalicular membrane more enriched than sinusoidal membrane	Protein	[115,116,132]
	GLUT4	Yes	Stellate cells	mRNA	[115,116,134]
	GLUT14	No
Class II	GLUT5	Yes	Normal liver tissue hepatocytes (cytoplasmic)	Both	[51,115]
	GLUT7	No			[140]
	GLUT9	Yes	Majority of expression in hepatocytes of normal liver and HCC with cytoplasmic expression in pericentral areas	Protein	[51]
	GLUT11	Yes		mRNA	[115]
Class III	GLUT6	Yes		mRNA	[76]
	GLUT8	Yes	Perivenous hepatocytes	Both	[115,143]
	GLUT10	Yes		mRNA	[86,115]
	GLUT12	Yes		mRNA	[98]
	GLUT13	No

The table summarizes the evidence presented within this review to highlight the reported hepatocellular expression of glucose transporter (GLUT) isoforms at message and protein level. Pertinent references are cited in the extreme right hand column. mRNA: Micro RNA; HCC: Hepatocellular carcinoma.