Small intestine bleeding due to multifocal angiosarcoma

Table 1 Literature overview: Angiosarcoma of the gastrointestinal tract (modified from Grewal et al[32] and Policarpio-Nicolas et al[47])

Patient[age (yr)/sex]	Tumor manifestation	Histology	Radiation/ pre-disposition	Symptoms	Therapy	Outcome	Ref.
46/M	Duodenum, ileum, and stomach	Epithelioid	None	Abdominal pain, melena	Resection	Died after 6 mo	[50]
65/F	Ileum	Well-differentiated	Radiation	Abdominal pain, nausea, vomiting	Resection, chemotherapy	Died after 14 mo	[39]
64/M	NA	Epithelioid	None	Gastrointestinal bleeding	Resection	Died after 1 yr	[29]
57/F	Small intestine	Epithelioid	None	NA	Resection	Died after 4 mo	[29]
47/F	Ileum	NA	Radiation	Abdominal pain	Resection, chemotherapy, radiation	NA	[40]
64/M	Small intestine	Well-differentiated tumor	None	Gastrointestinal bleeding	Resection	Died with disseminated disease after approximately 1 yr	[30]
57/M	Ileocecal valve, small bowel, and mesentery	Well-differentiated tumor	None	NA	Resection	Died after several days	[30]
76/M	Ileum	Mixed, well-differentiated and epithelioid	None	Abdominal pain, poor appetite, fatigue	Resection	Died after 9 d	[59]
74/F	Jejunum	Well-differentiated	NA	Melena	Resection	Died due to multiple complications	[60]
51/M	NA	Well-differentiated	Radiation	Abdominal pain	Resection, chemotherapy	Died after 5 mo	[48]
76/F	Ileum	Well-differentiated	Radiation	Abdominal pain, weight loss, vomiting, diarrhea	Resection	Died after 5 mo	[45]
48/F	Ileum	NA	Radiation	Abdominal pain	Resection	Died from sepsis after 23 d	[43]
60/F	Small intestine	Well-differentiated	Radiation	Acute abdomen, and a distal jejunal perforation	Resection	Died after 3 mo	[44]
80/F	Small and large bowel	Well-differentiated	Radiation	Altered intestinal function	Resection	Died after 2 wk	[42]
69/F	Small and large bowel	Well-differentiated	Radiation	Weight loss, abdominal distention, hematochezia	Resection	Died after 23 d	[42]
NA/M	Duodenum, stomach	Epithelioid	None	Severe melena	Resection	Died of respiratory failure, metastases were found in various organs, including the lungs, bones, liver, gall-bladder, and lymph nodes	[61]
78/F	Small intestine	High-grade	Radiation	Relative bowel obstruction	Resection	Died after 2 yr	[41]
50/F	Ileum	Multifocal and infiltrating	Radiation	Repeated symptoms of intestinal obstruction	Resection, chemotherapy	Died after 21 mo	[41]
61/F	Ileum	Well-differentiated	Radiation	Fullness, abdominal pain	Resection	Died after 10 mo	[46]
67/M	Jejunum, ileum	Epithelioid	None	Weight loss, Intermittent severe abdominal pain, and melena	Resection	Died after 3 mo	[51]
85/M	Small intestine	High-grade	None	Weight loss, decreased appetite, generalized weakness, left upper quadrant abdominal pain	Resection, chemotherapy	Survived at least 1 yr	[52]
59/M	Ileum	Mixed epithelioid and well-differentiated	None	Gastrointestinal bleeding	Resection	Died after 11 d	[37]
70/M	Duodenum	Epithelioid	None	Melena, anemia	Chemotherapy	Died after 4 mo	[49]
84/F	Jejunum	Epithelioid	None	Melena, anemia, shortness of breath	NA	Died after 17 mo	[49]
47/M	Jejunum	Epithelioid	None	Melena, anemia, shortness of breath	NA	Died after 4 mo	[49]
25/M	Small intestine	Epithelioid	None	Gastrointestinal bleeding, hemoptysis, anemia	Chemotherapy, radiation	Alive 18 mo after diagnosis, palliative situation	[49]
70/M	Ileum	Mixed, well-differentiated	None	Abdominal pain, vomiting	Resection, chemotherapy, radiation	Survived at least 4 yr	[53]
68/M	Ileocecal	High-grade	Radiation, polyvinyl chloride	Gastrointestinal bleeding, melena	Resection	Died before starting chemotherapy	[31]
51/F	Ileum	Well-differentiated	Radiation	Decreased appetite and vague abdominal pain of several months duration	Resection	Died after 10 mo	[47]
87/M	Duodenum, jejunum	Epithelioid	None	Lethargy, weakness, and nonspecific chest pain	Endoscopy, argon plasma coagulation	Died after 6 wk	[62]
73/M	Duodenum, jejunum	Epithelioid	Radiation	Weakness, dizziness, constipation, and melena	Resection	Died after 4 mo	[32]
NA/M	Jejunum	NA	NA	Acute abdominal signs	Resection, chemotherapy	Survived at least 3 yr	[2]
25/F	Small and large bowl	NA	None	Intermittent abdominal pain, weight loss, and progressive abdominal distension, a 7-wk history of shortness of breath, hematemesis, and melena	Resection	Died after 2 wk	[63]

NA: Not available; M: Male; F: Female.