Clinicopathological features of minute pharyngeal lesions diagnosed by narrow-band imaging endoscopy and biopsy

Table 1 Patient characteristics (n = 93)

Characteristics	No.
Age, yr (range)	67 (39-87)
Sex, men/women	80/13
Alcohol consumption
Yes	56 (54 men, 2 women)
No	30 (22 men, 8 women )
Smoker
Yes	57 (56 men, 1 woman)
No	29 (20 men, 9 women)
Esophageal cancer history
Yes	2
No	91
Other cancer history
Yes	9 (8 gastric cancer, 1 colon cancer)
No	84
Location
Hypopharynx	21 (17 men, 4 women)
Oropharynx	72 (63 men, 9 women)
Biopsy cases	62
High-grade dysplasia	3
Low-grade dysplasia	25
Non-dysplasia	34
ESD cases	17
High-grade dysplasia	2
Low-grade dysplasia	14
Non-dysplasia	1

ESD: Endoscopic submucosal dissection.

Table 2 Histological characteristics of the biopsied pharyngeal lesions n (%)

	Non-D	LGD	HGD
Number	34	25	3
IPCL
Upward extension	26 (76)	24 (96)	3 (100)
Dilatation and branching	5 (15)	21 (84)	3 (100)
Diameter expansion	0 (0)	8 (25)	1 (33)
Architectural atypia
Proliferative cell distribution
≥ 2/3	0 (0)	0 (0)	3 (100)
< 2/3	34 (100)	25 (100)	0 (0)
Tumor front	0 (0)	23 (92)	3 (100)
Cytological atypia
Abnormal variation in cell size	0 (0)	2 (8)	3 (100)
Abnormal nuclear arrangement	0 (0)	23 (92)	3 (100)
Increased nuclear size
High	0 (0)	0 (0)	3 (100)
Absent or low	34 (100)	25 (100)	0 (0)

Non-D: Non-dysplastic; LGD: Low-grade dysplasia; HGD: High-grade dysplasia; IPCL: Intra-papillary capillary loop.

Table 3 Diameters of the biopsied lesions n (%)

Diameter (mm)	n	Non-D	LGD	HGD
0.1-0.2	3	3 (100)	0 (0)	0 (0)
0.3-0.4	5	3 (60)	2 (40)	0 (0)
0.5-0.6	5	4 (80)	1 (20)	0 (0)
0.7-0.8	10	6 (60)	4 (40)	0 (0)
0.9-1.0	7	2 (29)	4 (57)	1 (14)
1.1-1.2	9	1 (11)	7 (78)	1 (11)
1.3-1.4	2	0 (0)	1 (50)	1 (50)
1.5-1.8	1	0 (0)	1 (100)	0 (0)
1.9-2.0	3	0 (0)	3 (100)	0 (0)

Non-D: Non-dysplasia; LGD: Low-grade dysplasia; HGD: High-grade dysplasia.