Effectiveness of Saccharomyces boulardii in a rat model of colitis

doi:10.3748/wjg.v18.i44.6452

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Nov 28, 2012 (publication date) through Nov 7, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2012; 18(44): 6452-6460
Published online Nov 28, 2012. doi: 10.3748/wjg.v18.i44.6452

Table 1 Study groups

Group	n	Application (day 1)	Application (days 1-14)
Control	4	Physiological serum	Physiological serum
TNBS	7	TNBS	No treatment
S. boulardii	7	TNBS	S. boulardii
MP	7	TNBS	MP
S. boulardii + MP	7	TNBS	S. boulardii + MP

TNBS: Trinitrobenzene sulfonic acid; S. boulardii: Saccharomyces boulardii; MP: Methyl prednisolone.

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Table 2 Disease activity index analysis¹

Score	Weight loss (%)	Stool consistency	Rectal bleeding
0	-	Normal	-
1	1-5	Loose stool	Occult blood in stool
2	5-10	Loose stool	Occult blood in stool
3	10-20	Loose stool	Occult blood in stool
4	> 20	Watery stool	Obvious blood in stool

¹Data are reported by Murthy et al [11].

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Table 3 Changes in body weight in the experimental groups

Groups	Baseline weight	Final weight	Difference in body weight
Control	214.0 ± 18.4	218.25 ± 19.6	4.3
TNBS	218.1 ± 18.6	230.0 ± 17.9	+ 11.9^a^b
S. boulardii	195.6 ± 9.1	198.0 ± 20.2	+ 2.4
MP	199.3 ± 9.1	196.33 ± 9.1	- 3.0
S. boulardii + MP	197.3 ± 10.7	191.43 ± 9.1	- 5.9

The results are shown as the mean ± SD.

^aP = 0.02 vs Saccharomyces boulardii (S. boulardii) + methyl prednisolone (MP);

^bP = 0.01 vs MP. TNBS: Trinitrobenzene sulfonic acid.

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Citation: Soyturk M, Saygili SM, Baskin H, Sagol O, Yilmaz O, Saygili F, Akpinar H. Effectiveness of Saccharomyces boulardii in a rat model of colitis. World J Gastroenterol 2012; 18(44): 6452-6460
URL: https://www.wjgnet.com/1007-9327/full/v18/i44/6452.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i44.6452