Brief Article
Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2012; 18(43): 6290-6301
Published online Nov 21, 2012. doi: 10.3748/wjg.v18.i43.6290
Table 1 Characteristics of included trials
TrialsSample size (n)
Mean age (yr)
Regimen (mg/d)
Duration(wk)Observationtime (wk)Outcome parametersHBV DNA undetectability (copy/mL)
LDTETVLDTETVLDTETV
Zhao et al[12]363634.306000.54824, 48ABDE-
Zhu et al[13]303028.00 ± 9.1031.80 ± 7.106000.52412, 24ABCDE1000
Zhou et al[14]526346.30 ± 9.006000.54812, 24, 36, 48ACD-
Xu et al[15]303032.70 ± 10.6033.60 ± 8.806000.52412, 24, 48ABCDF1000
Ye et al[16]464632.206000.54812, 24, 48ABCDE100
Zhang et al[17]756531.93 ± 7.966000.5728 ,12, 24, 52, 72ABDEF500
Liu[18]202033.506000.5484, 12, 24, 48ABCDF1000
Zhao et al[19]423933.56 ± 10.256000.5608, 12, 24, 48, 60ABD1000
Shi et al[20]404030.50 ± 7.1131.50 ± 7.956000.52412, 24ABCD500
Yu et al[21]92856000.5484, 8, 12, 24, 48ACD500
Huang et al[22]909028.80 ± 9.806000.55252ABCDE500
Ding et al[23]303037.20 ± 7.9636.10 ± 7.126000.5484, 8, 12, 24, 36, 48ABCDEF1000
Zheng et al[24]656631.60 ± 8.7033.50 ± 9.106000.52412, 24AFCDF500
Table 2 Sensitivity analysis
IndexTotal HBeAg loss
OR (95% CI)P vaule
Excluding the minimum sample size trials[18]1.64 (1.31, 2.05)< 0.00010
Using random-effect model1.68 (1.35, 2.09)< 0.00001
Using fixed-effect model1.69 (1.46, 1.97)< 0.00001