Copyright
©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 21, 2012; 18(43): 6290-6301
Published online Nov 21, 2012. doi: 10.3748/wjg.v18.i43.6290
Published online Nov 21, 2012. doi: 10.3748/wjg.v18.i43.6290
Trials | Sample size (n) | Mean age (yr) | Regimen (mg/d) | Duration(wk) | Observationtime (wk) | Outcome parameters | HBV DNA undetectability (copy/mL) | |||
LDT | ETV | LDT | ETV | LDT | ETV | |||||
Zhao et al[12] | 36 | 36 | 34.30 | 600 | 0.5 | 48 | 24, 48 | ABDE | - | |
Zhu et al[13] | 30 | 30 | 28.00 ± 9.10 | 31.80 ± 7.10 | 600 | 0.5 | 24 | 12, 24 | ABCDE | 1000 |
Zhou et al[14] | 52 | 63 | 46.30 ± 9.00 | 600 | 0.5 | 48 | 12, 24, 36, 48 | ACD | - | |
Xu et al[15] | 30 | 30 | 32.70 ± 10.60 | 33.60 ± 8.80 | 600 | 0.5 | 24 | 12, 24, 48 | ABCDF | 1000 |
Ye et al[16] | 46 | 46 | 32.20 | 600 | 0.5 | 48 | 12, 24, 48 | ABCDE | 100 | |
Zhang et al[17] | 75 | 65 | 31.93 ± 7.96 | 600 | 0.5 | 72 | 8 ,12, 24, 52, 72 | ABDEF | 500 | |
Liu[18] | 20 | 20 | 33.50 | 600 | 0.5 | 48 | 4, 12, 24, 48 | ABCDF | 1000 | |
Zhao et al[19] | 42 | 39 | 33.56 ± 10.25 | 600 | 0.5 | 60 | 8, 12, 24, 48, 60 | ABD | 1000 | |
Shi et al[20] | 40 | 40 | 30.50 ± 7.11 | 31.50 ± 7.95 | 600 | 0.5 | 24 | 12, 24 | ABCD | 500 |
Yu et al[21] | 92 | 85 | 600 | 0.5 | 48 | 4, 8, 12, 24, 48 | ACD | 500 | ||
Huang et al[22] | 90 | 90 | 28.80 ± 9.80 | 600 | 0.5 | 52 | 52 | ABCDE | 500 | |
Ding et al[23] | 30 | 30 | 37.20 ± 7.96 | 36.10 ± 7.12 | 600 | 0.5 | 48 | 4, 8, 12, 24, 36, 48 | ABCDEF | 1000 |
Zheng et al[24] | 65 | 66 | 31.60 ± 8.70 | 33.50 ± 9.10 | 600 | 0.5 | 24 | 12, 24 | AFCDF | 500 |
Index | Total HBeAg loss | |
OR (95% CI) | P vaule | |
Excluding the minimum sample size trials[18] | 1.64 (1.31, 2.05) | < 0.00010 |
Using random-effect model | 1.68 (1.35, 2.09) | < 0.00001 |
Using fixed-effect model | 1.69 (1.46, 1.97) | < 0.00001 |
- Citation: Su QM, Ye XG. Effects of telbivudine and entecavir for HBeAg-positive chronic hepatitis B: A meta-analysis. World J Gastroenterol 2012; 18(43): 6290-6301
- URL: https://www.wjgnet.com/1007-9327/full/v18/i43/6290.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i43.6290