Comparative effectiveness of i-SCAN™ and high-definition white light characterizing small colonic polyps

Table 1 Patient baseline characteristics n (%)

	All patients	Patients with polyps
Patients (n)	75	43
Age (yr), mean ± SD	60.6 ± 9.58	61.9 ± 8.98
Male sex	43 (57.3)	31 (72.1)
Race1
White	56 (75.7)	33 (78.6)
Black	15 (20.3)	7 (16.67)
Other	3 (4.00)	2 (4.76)
Proportion of patients with +family history of colorectal cancer	14 (19.2)	10 (23.8)
Proportion of patients with personal history of adenomatous polyps	24 (32.9)	32 (74.4)
Prep quality
Excellent	14 (19.2)	7 (17.5)
Good	48 (65.8)	27 (67.5)
Fair	10 (13.7)	5 (12.5)
Poor	1 (1.4)	1 (2.5)

¹Missing data includes family history (n = 2) and prep quality (n = 2).

Table 2 Endoscopist quality measures

	Endoscopist A	Endoscopist B
Patients (n)	48 (64)	27 (36)
Polyps/patient (n/n), mean ± SD	1.5 ± 1.7	1.2 ± 1.9
Polyp size (mm), mean ± SD	3.67 ± 1.39	3.77 ± 1.04
Cases in which polyp identified n (%)	29 (60.4)	14 (51.9)
Cases in which adenomatous polyp identified n (%)	22 (45.8)	10 (37.0)
Procedure time (min), mean ± SD	21 ± 6.8a	26 ± 9.6a

^aP < 0.05 vs Endoscopist A.

Table 3 Test characteristics for adenoma prediction, % (95%CI)

	Combined	Endoscopist A	Endoscopist B
White light
Accuracy	71.8 (62.1-80.3)	63.0 (50.9-74.0)	93.3 (77.9-99.2)
Sensitivity	74.1 (60.4-85.0)	66.7 (49.0-81.4)	88.9 (65.3-98.6)
Specificity	69.4 (54.6-81.8)	59.5 (42.1-75.3)	100 (73.5-100)
Positive predictive value	72.7 (61.0-84.5)	61.5 (44.8-77.5)	100 (79.4-100)
Negative predictive value	70.8 (58.0-83.7)	64.7(46.5-80.3)	85.7(57.2-98.2)
i-SCAN
Accuracy
Total	71.8 (62.1-80.3)	63.0 (50.9-74.0)	93.3 (77.9-99.2)
First Half	71.4 (57.8-82.7)	59.0 (42.1-74.4)	100 (80.5-100)
Second half	72.3 (57.4-84.4)	67.6 (49.5-82.6)	84.6 (54.6-98.1)
Sensitivity	72.2 (58.4-83.5)	63.9 (46.2-79.2)	88.9 (65.3-98.6)
Specificity	71.4 (56.7-83.4)	62.2 (44.7-77.5)	100 (73.5-100)
Positive predictive value	73.6 (61.7-85.5)	62.2 (44.6-76.6)	100 (79.4-100)
Negative predictive value	70.0 (57.3-82.7)	63.9 (46.2-79.2)	85.7 (57.2-98.2)