Multimodality approach for locally advanced esophageal cancer

Table 1 Randomized trials of preoperative radiotherapy vs surgery alone

Ref.	Number of patients	Median survival (mo)		5-yr survival1 (%)
		+RT	-RT	+RT	-RT
Launois et al[11]	124	4.5	8.2	10	12
Gignoux et al[12]	229	12.3	12	10	9
Wang et al[13]	206	-	-	35	30
Nygaard et al[14]	108	10	7	-	-
Arnott et al[15]	196	8	8	9	17
Fok et al[3]	79	11	22	10	16

¹Not statistically significant. RT: Radiotherapy.

Table 2 Randomized trials of preoperative chemotherapy vs surgery alone

Ref.	Number of patients	Chemotherapy	Median survival (mo)		3-yr survival (%)
			+CT	-CT	+CT	-CT
Roth JA et al[22]	39	CDDP/bleomycin/vindesin	> 201	8.6	-	-
Nygaard et al[14]	112	CDDP/bleomycin	7	7	3	9
Schlag[23]	46	CDDP/5-FU	7.5	5	-	-
Maipang et al[25]	46	CDDP/bleomycin	17	17	31	36
Law et al[24]	147	CDDP/5-FU	16.8	13	38	14
Kelsen et al[56]	440	CDDP/5-FU	14.9	16.1	42	45
MRC[26]	802	CDDP/5-FU	16.8	13.3	35	27
Ancona et al[28]1	94	CDDP/5-FU	25	24	44	41
Cunningham et al[27]1 503		ECF	-	-	79	50

¹The difference in survival was statistically significant. MRC: Medical Research Council Oesophageal Cancer Working Group; CDDP: Cisplatin; 5-FU: 5-flurouracil; ECF: Epirubicin, cisplatin and 5-fluorouracil; CT: Chemotherapy.

Table 3 Randomized trials of preoperative chemotherapy and radiation vs surgery alone

Ref.	Number of patients	Chemotherapy	Median survival (mo)		3-yr survival (%)
			+CRT	-CRT	+CRT	-CRT
Nygaard et al[14]1	103	CDDP/bleomycin	7	7	17	9
Le Prise et al[39]	86	CDDP/5-FU	11	11	19	14
Apinop et al[40]	69	CDDP/5-FU	9.7	7.4	26	20
Walsh et al[47]1	113	CDDP/5-FU	16	11	32	6
Bosset et al[38]	282	CDDP	18.6	18.6	39	37
Urba et al[46]	100	CDDP/vinblastine/5-FU	17.6	16.9	30	16
Burmeister et al[43]	257	CDDP/5-FU	22	19	-	-
Lee et al[48]	101	CDDP/5-FU	28.2	27.3	-	-
Tepper[45]1	56	CDDP/5-FU	53	21	-	-
van Hagen[41]1	386	Carbo/paclitaxel	49	24	58	44

¹The difference in survival was statistically significant. CDDP: Cisplatin; 5-FU: 5-flurouracil; CRT: Chemotherapy and radiation.