Carbon dioxide accumulation during analgosedated colonoscopy: Comparison of propofol and midazolam

Table 1 Demographic data of the randomized groups

	Sedation with Midazolam(n = 42)	Sedation with Propofol(n = 41)	P value
Age (yr, mean ± SD)	62 ± 13	62 ± 13	NS
M : F (n)	19:23	20:21	NS
ASA I	12 (29%)	13 (32%)	NS
ASA II	16 (38%)	15 (37%)	NS
ASA III	14 (33%)	13 (32%)	NS
Smoker	6 (15%)	6 (15%)	NS
Mean dosage of sedative in mg (range)	5 (4-7)	131 (70-260)	-

ASA: American Society of Anesthesiologists classification; NS: Not significant.

Table 2 Oxygen saturation measured by pulse oximetry at baseline and changes during endoscopy according to sedatives

	Midazolam(n = 42)	Propofol(n = 41)	P value
SpO2 at baseline (%)	99 ± 1	99 ± 1	NS
Mean max decrease of SpO2 (%)	6 ± 3	4 ± 2	NS

SpO₂: Oxygen saturation measured by pulse oximetry; NS: Not significant.

Table 3 Procedure outcomes according to the defined endpoints (n)

	Midazolam(n = 42)	Propofol(n = 41)	P value
ΔPcCO2 < ± 1.5 mmHg (from baseline and five min after end)	12	32	0.0004
SpO2 < 85%	0	0	NS
SpO2 < 90%	6	0	0.05
HR < 50 bpm	5	1	NS
Decrease MAP > 25%	17	17	NS

HR: Heart rate; MAP: Mean arterial pressure; SpO₂: Oxygen saturation measured by pulse oximetry; ΔPcCO₂: Difference of transcutaneous carbon dioxide tension; NS: Not significant.