Safety and effectiveness of propofol sedation during and after outpatient colonoscopy

Table 1 Demographic and clinical data in 2101 patients who underwent colonoscopy using propofol sedation

	n (%)
Sex: Male	1149 (55)
Mean age (range) (yr)	66 (20-94)
Mean body weight (range) (kg)	56.7 (32-98)
Indication
Screening	785 (37)
Hemopositive stool	538 (26)
Abdominal symptoms	406 (19)
Hematochezia	140 (7)
Surveillance	133 (6)
Anemia	70 (3)
Others	29 (1)
Propofol dose (mg):
About 40	110 (5)
60	239 (11)
80	623 (30)
100-120	973 (46)
140-160	131 (6)
180-200	25 (1)
Successful procedure	2101 (100)
Mean procedure time (range) (min)	14 (8-46)
Oxygen administered	5 (0.2)
Mask ventilation required	0 (0)
Heart rate < 50 beats/min	0 (0)
Complications	0 (0)
Full recovery 60 min after the procedure	2101 (100)

Values are numbers (percentages) of patients except for mean age, mean body weight, and mean procedure time.

Table 2 Relationship between age or sex and dose of propofol used in 2101 patients who underwent colonoscopy

Age (yr)	No. (M/F)	Propofol dose (mg)			P value
		Total (range)	Male	Female
20-401	150 (89/61)	115.3 ± 32 (40-200)	113.4 ± 27	118.2 ± 24	0.43
41-60	563 (316/247)	107.7 ± 27 (40-200)	106.9 ± 28	108.7 ± 25	0.19
≥ 61	1388 (744/644)	89.7 ± 21 (40-200)	87.7 ± 23	92.1 ± 19	0.32
Total	2101 (1149/952)	96.4 ± 27	95.0 ± 26	98.1 ± 25	0.18

Values are mean ± SD except for number of patients and range of dose used of propofol. P value shows the difference between male and female patients.

¹There were significant differences in the doses of propofol in each group between age 20-40 and ≥ 61 years (P < 0.001).

Table 3 Demographic data and results of questionnaires in 1820 patients who underwent colonoscopy using propofol sedation

Sex: Male	954 (52)
Mean age (range) (yr)	65 (33-80)
Mean body weight (range) (kg)	58.7 (45-98)
Did you find propofol sedation for your colonoscopy satisfactory?
Excellent	1456 (80%)
Good	309 (17%)
No	11 (0.6%)
NA	8 (2.4%)
Did you drive home or to the office after your colonoscopy?
Yes	1183 (65%)
No	637 (35%)
Did you experience any accidents within 24 h after your colonoscopy?
Yes	0 (0%)
No	1820 (100%)
Do you want to repeat the same procedure next time?
Yes	1805 (99%)
No	15 (1%)

Values are numbers (percentages) of patients except for mean age and mean body weight. NA: Not available.