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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 7, 2012; 18(21): 2654-2660
Published online Jun 7, 2012. doi: 10.3748/wjg.v18.i21.2654
Published online Jun 7, 2012. doi: 10.3748/wjg.v18.i21.2654
Baseline characteristics | Number of patients |
Age (yr) | 50.2 ± 9.4 |
Male | 84 (59.2) |
Etiology of liver disease | |
Hepatitis B infection | 126 (88.7) |
Hepatitis C infection | 9 (6.3) |
Alcohol liver cirrhosis | 7 (5.0) |
Liver cirrhosis | 111 (78.2) |
Child-Pugh A | 98 (88.3) |
Child-Pugh B | 10 (9.0) |
Child-Pugh C | 3 (2.7) |
AST (UI/L) | 47.9 ± 26.8 |
ALT (UI/L) | 53.2 ± 42.5 |
PT (INR) | 1.19 ± 0.17 |
Bilirubin (mg/dL) | 1.24 ± 0.97 |
Platelets (109/L) | 125.3 ± 60.3 |
Albumin (g/dL) | 3.77 ± 0.56 |
Baseline AFP (ng/mL, range) | 5.7 (1.0-211.6) |
Number of nodules | |
One | 26 (18.3) |
Two | 7 (5.0) |
Three | 3 (2.1) |
Four | 1 (0.7) |
Over four | 105 (73.9) |
Nodule pattern | |
Hypoechoic/low-attenuation | 77 (54.3) |
Hyperechoic/high-attenuation | 31 (21.8) |
Mixed | 34 (23.9) |
Initial radiologic diagnosis | |
RN/DN | 119 (83.8) |
Hemangioma | 17 (12.0) |
Indeterminate nodule | 5 (3.5) |
Arterioportal shunt | 1 (0.7) |
Variables | Diagnosis | P value | |
HCC (n = 33) | Non-HCC (n = 109) | ||
Age (yr) | 54.4 ± 8.3 | 48.9 ± 9.4 | 0.003 |
Male | 24 (72.4) | 60 (55.0) | 0.070 |
Etiology of liver disease | 0.364 | ||
Hepatitis B infection | 27 (81.8) | 99 (90.8) | |
Hepatitis C infection | 3 (9.1) | 6 (5.5) | |
Alcoholic liver cirrhosis | 3 (9.1) | 4 (3.7) | |
Liver cirrhosis | 29 (87.9) | 82 (75.2) | 0.123 |
AST (UI/L) | 49.3 ± 20.4 | 47.5 ± 28.5 | 0.736 |
ALT (UI/L) | 50.9 ± 36.5 | 53.9 ± 44.3 | 0.722 |
PT (INR) | 1.23 ± 0.17 | 1.18 ± 0.17 | 0.088 |
Bilirubin (mg/dL) | 1.27 ± 0.78 | 1.23 ± 1.02 | 0.831 |
Platelets (109/L) | 110.1 ± 53.9 | 129.9 ± 61.6 | 0.099 |
Albumin (g/dL) | 3.56 ± 0.58 | 3.84 ± 0.55 | 0.012 |
Number of nodules | 0.390 | ||
One | 4 (12.1) | 22 (20.0) | |
Two | 1 (3.0) | 6 (5.5) | |
Three | 0 (0.0) | 3 (2.8) | |
Four | 0 (0.0) | 1 (0.9) | |
Over four | 28 (84.8) | 77 (70.6) | |
Nodule pattern | 0.011 | ||
Hypoechoic/low-attenuation | 23 (69.7) | 54 (49.5) | |
Hyperechoic/high-attenuation | 1 (3.0) | 30 (27.5) | |
Mixed | 9 (27.3) | 25 (22.9) | |
Initial radiologic diagnosis | 0.036 | ||
RN/DN | 31 (93.9) | 88 (80.7) | |
Hemangioma | 0 (0.0) | 17 (15.6) | |
Indeterminate nodule | 2 (6.1) | 3 (2.8) | |
Arterioportal shunt | 0 (0.0) | 1 (0.9) | |
Baseline AFP (ng/mL, range) | 8.5 (3.2-211.6) | 5.4 (1.0-55.9) | 0.035 |
Variables | P value | OR | 95% CI |
Age (yr) | 0.012 | 1.075 | 1.016-1.137 |
Male | 0.009 | 3.969 | 1.403-11.226 |
PT (INR) | 0.877 | 0.698 | 0.007-66.718 |
Platelets (109/L) | 0.917 | 0.999 | 0.990-1.009 |
Albumin (g/dL) | 0.478 | 0.624 | 0.169-2.298 |
Nodule pattern | 0.081 | ||
Nodule pattern (1)1 | 1.000 | 0.812 | 0.233-2.827 |
Nodule pattern (2)2 | 0.054 | 0.075 | 0.006-1.026 |
Baseline AFP (ng/mL) | 0.024 | 1.039 | 1.005-1.073 |
- Citation: Min YW, Gwak GY, Lee MW, Choi MS, Lee JH, Koh KC, Paik SW, Yoo BC. Clinical course of sub-centimeter-sized nodules detected during surveillance for hepatocellular carcinoma. World J Gastroenterol 2012; 18(21): 2654-2660
- URL: https://www.wjgnet.com/1007-9327/full/v18/i21/2654.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i21.2654