Immune mechanisms of Concanavalin A model of autoimmune hepatitis

Table 1 The features of the autoimmune hepatitis model induced by endotoxins and plant lectins

	Con A[29]	GalN/LPS[29]	LPS[29]
Animal	BALB/c-mice	BALB/c-mice	BALB/c-mice
	(6-8 wk)	(6-8 wk)	(6-8 wk)
Inducer	Con A	GalN/LPS	LPS
Dosage	20 mg/kg	LPS: 5 μg/kg	10 mg/kg
		GalN: 700 mg/kg
Application method	Tail vein	Subcutaneous	Subcutaneous
Transaminase level (max)	8 h	8 h	No significant change

Con A: Concanavalin A; GalN: D-galactosamine; LPS: Lipopolysaccharides.

Table 2 New drugs developed based on the Concanavalin A model

	Classification	Target	Pathway
Hu 23C3[63]	Monoclonal antibody	Human osteopontin	NF-κB
Anti-his H1[64]	Polyclonal antibody	Histone H1	NF-κB
ApoA II[65]	High density lipoprotein	Leukocytes and T cells	-
CpG ODN[66]	Oligodeoxynucleotides	DNA binding ability of NF-κB	NF-κB

CpG ODN: CpG-containing oligodeoxynucleotides; ApoA: Apolipoprotein A; Anti-his H1: Antibody against histone H1; NF-κB: Nuclear factor kappa B.