Rifaximin, but not growth factor 1, reduces brain edema in cirrhotic rats

Table 1 Biochemical features of groups studied

	Endotoxin (EU)	Glucose (mmol/L)	Bilirubin (μmol/L)	ALT (UI/L)	AST (UI/L)
Cirrhosis	0.582 ± 0.069a	9.41 ± 2.17a	22.0 ± 6.71ac	181.2 ± 16.1a	333.2 ± 84.2a
Controls	0.374 ± 0.037	27.63 ± 2.39	2.9 ± 0.15	68.9 ± 9.9	228.3 ± 24.6
Cirrhosis + IGF-1	0.432 ± 0.033	9.43 ± 0.70a	10.2 ± 2.96a	210.3 ± 58.6a	482.3 ± 121.8a
Controls + IGF-1	0.363 ± 0.032	25.17 ± 2.42	3.2 ± 0.10	94.4 ± 22.1	179.2 ± 30.1
Cirrhosis + R	0.410 ± 0.041	17.75 ± 3.06e	5.0 ± 1.23	121.4 ± 18.4	262.1 ± 49.1
Controls + R	0.368 ± 0.027	29.39 ± 2.08	3.1 ± 0.20	97.7 ± 23.4	236.2 ± 43.2

^aP < 0.05 vs all control groups;

^cP < 0.05 vs cirrhosis + R;

^eP < 0.05 vs control + R. IGF: Insulin-like growth factor; R: Rifaximin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.