Experience after 100 patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Table 1 Tumor type and primary tumor nodes status

Tumor type	n
Colon	21
Rectal	5
Appendiceal	10
Ovarian	33
Pseudomyxoma	13
Stomach	11
Mesothelioma	1
Other	6
Tumor	n (%)
1	5 (5)
2	9 (9)
3	44 (44)
4	42 (42)
Nodes	n (%)
0	33 (33)
1	39 (39)
2	24 (24)
3	4 (4)

Table 2 Clinical characteristics

Patients	n = 100
Age (yr)	54 (17-76)
American Society of Anesthesiologists [n (%)]
1	7 (7)
2	52 (52)
3	41 (41)
BMI (cm/kg2)	24 (17-41)
Time to PC from primary diagnosis (d)	365 (103-1009)

Data are presented as mean (min-max) or n (%). PC: Peritoneal carcinomatosis; BMI: Body mass index.

Table 3 Intraoperative data

PCI score	17 (1-39)
Operating time (min)	593 (178-1076)
CC Status	n (%)
0	56 (56)
1	33 (33)
2	11 (11)

Intraoperative peritoneal carcinomatosis index (PCI) and complete cytoreduction (CC) status, operating time.

Table 4 Type of hyperthermic intraperitoneal chemotherapy and resection

HIPEC type	%
Mitomycin C	60
Cisplatin	32
Mitomycin C and Cisplatin	5
Other	3
Parietal peritonectomy	90
Gastrectomy	18
Ileo-coecal resection	18
Colonic resection	19
Anterior rectal resection	35
Right hemicolectomy	28
Sigmoideal resection	11
Small bowel resection	28
Omental resection	33
Cholecystectomy	22
Hysterectomy	22
Ovarectomy/adnexectomy	14
Splenectomy	35
Atypical liver resection	9
Pancreatic resection	5
Removal of part of the diaphragm	15
Tumor resection in the abdominal wall	1
Ureteral resection	1

Type of operation during complete cytoreduction and hyperthermic intraperitoneal chemotherapy.

Table 5 Complications and mortality

Cumulative complications, n	94
30-d mortality, n (%)	1
90-d mortality, n (%)	0

Cumulative complications and mortality; data are presented as median (min, max).

Table 6 Types of complication

Types of complication	n (%)
Cardiac	1 (1)
Pneumonia	5 (5)
Sepsis	3 (3)
Thrombembolic	9 (9)
Postoperative bleeding	2 (2)
Ureter injury	3 (3)
Wound infection	21 (21)
Leukopenia	29 (29)
Anastomotic leakage	8 of 139 (5.8)
Compartment syndrome	1 (1)
Transient paresthesia in the legs	1 (1)
Pancreatic fistula	0
Reoperation due to complication	21 (21)
DINDO complication classification	%
0	52
1	23
2	10
3	3
4	11
5	1

Complications and complications according to DINDO classification.

Table 7 Neither peritoneal carcinomatosis index, body mass index nor age had a significant influence on perioperative complications according to the DINDO classification n (%)

	PCI < 20	PCI≥20	P value	Correlation coefficient
DINDO 0	34 (55)	18 (48)	0.128	0.07
DINDO 1-2	22 (35)	10 (26)
DINDO 3-5	6 (10)	10 (26)
	Age < 65	Age ≥ 65
DINDO 0	45 (55)	9 (50)	0.917	-0.0028
DINDO 1-2	25 (30)	6 (33)
DINDO 3-5	12 (15)	3 (17)
	BMI < 25	BMI ≥ 25
DINDO 0	35 (60)	17 (41)	0.075	0.19
DINDO 1-2	17 (30)	14 (33)
DINDO 3-5	6 (10)	11 (26)

PCI: Peritoneal carcinomatosis index; BMI: Body mass index.