Analysis of infections in the first 3-month after living donor liver transplantation

Table 1 Univariate analysis for risk factors for postoperative bacterial infection

Variables	Infected	No infected	P value
Donor variables
Age (yr)	34.45 ± 8.78	34.89 ± 10.19	0.825
Gender (female)	10	71	0.580
BMI (kg/m2)	22.80 ± 2.69	22.99 ± 2.53	0.711
Recipient variables
Age (yr)	46.72 ± 8.27	42.31 ± 8.63	0.012
Gender (female)	2	25	0.384
BMI (kg/m2)	21.77 ± 4.21	22.63 ± 2.93	0.172
MELD score	17.24 ± 7.40	16.26 ± 10.18	0.621
Renal dysfunction	1	15	0.705
Diabetes mellitus	1	8	0.798
Starting albumin level < 2.8 g/dL	10	32	0.040
Starting TB level ≥ 20 mg/dL	3	24	0.774
Starting INR level	1.62 ± 0.54	1.71 ± 1.50	0.744
Hyponatremia	7	12	0.008
Graft variables
GRWR (%)	0.99 ± 0.23	0.93 ± 0.17	0.111
Intraoperative variables
Massive RBCs transfusion	8	35	0.335
FFP transfusion > 10 units	7	42	0.949
Postoperative variables
Bile leak	10	6	0.000
Rejection	2	3	0.090
Hyperglycemia	5	10	0.042
ICU stay	17.38 ± 11.11	12.28 ± 12.48	0.040

BMI: Body mass index; MELD: Model for end-stage liver disease; TB: Total bilirubin; INR: International normalized ratio; GRWR: Graft to recipient weight ratio; RBC: Red blood cell; FFP: Fresh frozen plasma; ICU: Intensive care unit.

Table 2 Multivariate analysis for risk factors for postoperative bacterial infection

						95% CI
Variables	B	SE	Wald	P value	Exp (B)	Lower	Upper
Bile leak	1.890	0.421	20.156	0.000	6.622	2.901	15.116
Hyponatremia	1.512	0.487	9.649	0.002	4.535	1.747	11.770
Hyperglycemia	1.171	0.508	5.308	0.021	3.226	1.191	8.737
ICU stay > 9 d	0.932	0.458	4.145	0.042	2.540	1.035	6.230
Recipient age > 45 yr	1.253	0.408	9.440	0.002	3.501	1.574	7.785

SE: Standard error; CI: Confidence interval; ICU: Intensive care unit.

Table 3 Univariate analysis for risk factors for postoperative fungal infection

Variables	Infected	No infected	P value
Donor variables
Age (yr)	37.00 ± 7.76	34.73 ± 10.08	0.507
Gender (female)	4	74	0.739
BMI (kg/m2)	21.64 ± 2.27	23.02 ± 2.54	0.110
Recipient variables
Age > 45 yr	5	62	0.153
Gender (female)	1	26	0.860
BMI (kg/m2)	21.44 ± 2.80	22.56 ± 3.16	0.295
MELD score	20.11 ± 9.35	16.23 ± 9.85	0.248
Renal dysfunction	1	15	0.698
Diabetes mellitus	0	9	0.513
Starting albumin level < 2.8 g/dL	3	39	0.391
Starting total bilirubin level	2	25	0.332
Starting INR level	1.91 ± 0.55	1.69 ± 1.43	0.650
Hyponatremia	3	16	0.010
Graft variables
GRWR (%)	0.93 ± 0.21	0.94 ± 0.18	0.886
Intraoperative variables
Massive RBCs transfusion	6	37	0.003
FFP transfusion > 10 units	4	45	0.220
Postoperative variables
Bile leak	1	15	0.698
Rejection	0	5	0.629
Hyperglycemia	2	13	0.076
ICU stay > 9 d	5	98	0.748
Postoperative bacterial infection	6	23	0.000

BMI: Body mass index; MELD: Model for end-stage liver disease; INR: International normalized ratio; GRWR: Graft to recipient weight ratio; RBC: Red blood cell; FFP: Fresh frozen plasma; ICU: Intensive care unit.

Table 4 Multivariate analysis for risk factors for postoperative fungal infection

						95% CI
Variables	B	SE	Wald	P value	Exp (B)	Lower	Upper
Massive RBCs transfusion	1.887	0.710	7.062	0.008	6.599	1.641	26.542
Bacterial infection	2.429	0.711	11.686	0.001	11.346	2.819	45.673

SE: Standard error; CI: Confidence interval; RBC: Red blood cell.