Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma

Table 1 Rab27A status in relation to clinicopathological features in patients with hepatocellular carcinoma (%)

	No. of cases	Positive	Negative	P value
Rab27A clinicopathological features
All patients	148
Gender
Male	108 (75.5)	47 (43.5)	61 (56.5)
Female	35 (24.5)	19 (54.3)	16 (45.7)	NS
Age at diagnosis
< 60	116 (81.1)	51 (44)	65 (56)
≥ 60	27 (18.9)	15 (56.6)	12 (43.5)	NS
Carcinoma and adjacent tissue
Carcinoma tissue	143 (51)	66 (46.2)	77 (53.8)
Adjacent tissue	136 (49)	33 (24.3)	103 (75.7)	< 0.001
Hepatic and cirrhosis tissue
Normal hepatic tissue	40 (44.4)	10 (25)	30 (75)
Hepatitis and cirrhosis tissue	50 (55.6)	13 (26)	37 (74)	NS
Degree of differentiation
Well	39 (27.3)	2 (5.1)	37 (94.9)
Moderate	91 (63.6)	9 (9.9)	82 (90.1)
Poor	13 (9.1)	5 (38.5)	8 (61.5)	0.0081
TNM classification
Stage I/II	106 (74.1)	41 (38.7)	65 (61.3)
Stage III/IV	37 (25.9)	25 (67.7)	12 (32.4)	0.002
HBV
Negative	26 (19.4)	10 (38.5)	16 (61.5)
Positive	108 (80.6)	53 (49.1)	55 (50.9)	NS
AFP
Negative	42 (32.5)	15 (35.7)	27 (64.3)
Positive	88 (67.7)	43 (48.9)	45 (51.1)	NS
Type of hepatoma
Nodular	84 (66.7)	39 (46.4)	45 (53.6)
Massive	33 (26.2)	12 (36.4)	21 (63.6)
Diffuse	9 (7.1)	5 (55.6)	4 (44.4)	NS
Rab27B clinicopathological features
All patients	148
Gender
Male	106 (75.2)	61 (57.5)	45 (42.5)
Female	35 (24.8)	20 (57.1)	15 (42.9)	NS
Age at diagnosis
< 60	114 (80.9)	65 (57)	49 (43)
≥ 60	27 (19.1)	16 (59.3)	11 (40.7)	NS
Carcinoma and adjacent tissue
Carcinoma tissue	141 (51)	81 (57.4)	60 (42.6)
Adjacent tissue	136 (49)	119 (87.5)	17 (12.5)	< 0.001
Hepatic and cirrhosis tissue
Normal hepatic tissue	40 (44)	29 (72.5)	11 (27.5)
Hepatitis and cirrhosis tissue	50 (56)	38 (76)	12 (24)	NS
Degree of differentiation
Well	39 (27.5)	26 (66.7)	13 (33.3)
Moderate	89 (63.4)	49 (53.9)	41 (46.1)
Poor	13 (9.2)	8 (61.5)	5 (38.5)	NS
TNM classification
Stage I/II	103 (73)	51 (49.5)	52 (50.5)
Stage III/IV	38 (27)	30 (78.9)	8 (21.1)	0.002
HBV
Negative	27 (19.9)	17 (63)	10 (37)
Positive	109 (80.1)	59 (54.1)	50 (45.9)	NS
AFP
Negative	43 (33.6)	23 (53.5)	20 (46.5)
Positive	85 (66.4)	49 (57.6)	36 (42.4)	NS
Type of hepatoma
Nodular	84 (66.7)	40 (47.6)	44 (52.4)
Massive	33 (26.2)	15 (45.5)	18 (54.5)
Diffuse	9 (7.1)	6 (66.7)	3 (33.3)	NS

¹Comparing the strong positive group with the other groups. TNM: Tumor-node-metastasis; NS: Not significant; HBV: Hepatitis B virus; AFP: Alpha fetoprotein.