No evidence of circulating autoantibodies against osteoprotegerin in patients with celiac disease

Table 1 Characteristics of the 70 treated celiac disease patients with negative serology according to bone mineral density as assessed by dual energy X ray absorptiometry

Variables	Overall (n = 70)	Normal BMD(n = 21)	Low BMD(n = 49)	P
Sex (M/F)	13/57	2/19	11/38	0.31
Age (yr)	40.5 ± 10.5	31.0 ± 9.7	43.0 ± 9.7	0.00
Time since diagnosis	2.8 ± 0.6	2.5 ± 0.5	2.4 ± 0.4	0.37
BMI	22.2 ± 1.4	22.5 ± 1.3	22.0 ± 1.4	0.40
Smoke	13	3	10	0.74
Fracture	0	0	0	-
Menopausal status	6	0	6	0.17

BMD: Bone mineral density; BMI: Body mass index; M: Male; F: Female.

Table 2 Bone mineral density according to dual energy X ray absorptiometry in celiac disease patients with and without duodenal mucosa healing after gluten free diet

	Duodenal mucosa healing	Duodenalmucosa lesions	Total
Low BMD	20	6	26
Normal BMD	11	1	12
Total	31	7	38

BMD: Bone mineral density.

Table 3 Characteristics of the 30 celiac disease patients who underwent measurement of serum antibodies against osteoprotegerin

Variables	Overall (n = 30)	Normal BMD (n = 6)	Low BMD (n = 24)
Sex (M/F)	8/22	1/5	7/17
Age (yr)	43.5 (21-60)	31.0 (21-54)	44.5 (32-60)
Time since diagnosis (yr)	2.8 (1.0-3.5)	2.7 (1.8-3.2)	2.9 (1.0-3.5)
BMI (kg/m2)	22.3 (19.2-25.1)	21.8 (19.2-24.7)	22.4 (20.0-25.1)
Smoke	4	0	4
Fracture	0	0	0
Menopausal status	1	0	1
Duodenal mucosa histology (n = 22)
Healing	17	5	12
Lesions	5	1	4
HLA status
DQ2	23	4	19
DQ8	7	2	5

BMD: Bone mineral density; BMI: Body mass index; HLA: Human leukocyte antigen.